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Author:   Hilmar Weinmann (Janssen Pharmaceutica N.V., Belgium) ,  Craig Crews (Yale University, USA) ,  Nello Mainolfi ,  Randy Teel
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 74
Weight:   0.733kg
ISBN:  

9781788016865

ISBN 10:   1788016866
Pages:   380
Publication Date:   08 October 2020
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?; Structural and Biophysical Principles of Degrader Ternary Complexes; Immediate and Selective Control of Protein Abundance using the dTAG System; Developing Pharmacokinetic/Pharmacodynamic Relationships with PROTACs; New Activities of CELMoDs, Cereblon E3 Ligase Modulating Drugs; Structure-based PROTACs Design; Plate-Based High Throughput Cellular Degradation Assays to Identify PROTACS Molecules and Protein Degraders; PROTAC Targeting BTK for the Treatment of Ibrutinib-Resistant B-Cell Malignancies; An Efficient Approach Toward Drugging Undruggable Targets; E3-Mediated Ubiquitin and Ubiquitin-like Protein Ligation: Mechanisms and Chemical Probes; Plant E3 Ligases as Versatile Tools for Novel Drug Development and Plant Bioengineering; Deubiquitinase Inhibitors: An Emerging Therapeutic Class; Targeting Translation Regulation for the Development of Novel Drugs; Classes, Modes-of-action and Selection of New Modalities in Drug Discovery; Small Molecule Targeted Degradation of RNA

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