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OverviewProkaryotic Toxins – Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has »100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level. Full Product DetailsAuthor: Kenn GerdesPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: 2013 ed. Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 5.679kg ISBN: 9783642446573ISBN 10: 3642446574 Pages: 368 Publication Date: 09 November 2014 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsIntroduction.- Type I Toxin – Antitoxin Systems: Hok/Sok and Fst .- Novel Type I Toxin – Antitoxin Systems.- Type II TA Loci: The Ccdab and Parde Families.- Type II TA Loci: The Relbe Family.- Type II TA Loci: The Unusual Mqsra Locus.- Type II TA Loci: The Mazef Family.- Type II TA Loci: Vapbc and Other TA Loci In Mycobacteria.- Type II TA Loci: Phd Doc Family.- Type II TA Loci: The Fic Family.- Type II TA Loci, Hipab And Persisters.- Type II TA Loci: Zeta/Pezt Family.- Type II Loci: Phylogeny.- Type III TA Loci.- TA Loci Encoded By Plasmids.- TA Loci in Archaea.- TA Loci in Mycobacterium Tuberculosis.- TA Loci in Streptococcus Pneumoniae.- Biotechnological and Medical Exploitations Of TA Genes and Their Components.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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