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OverviewProkaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful. Full Product DetailsAuthor: Simon Baumberg (Professor of Bacterial Genetics, School of Biology, University of Leeds)Publisher: Oxford University Press Imprint: Oxford University Press Volume: 21 Dimensions: Width: 18.90cm , Height: 2.00cm , Length: 24.50cm Weight: 0.641kg ISBN: 9780199636037ISBN 10: 0199636036 Pages: 346 Publication Date: 27 May 1999 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Out of Print Availability: In Print  Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock. Table of Contents1: History and overview 2: Protein recognition of specific DNA and RNA bonding sites 3: Promoters, sigma factors, and variant RNA polymerases 4: Repressors and activators 5: Post-transcriptional control 6: Prokaryotic DNA topology and gene expression 7: Integration of control devices: A global regulatory network in Escherichia coli. 8: Two component systems 9: Switch systems 10: Integration of control devices I. Pathogenecity 11: Integration of control devices II. Sporulation and antibiotic production 12: Evolution of prokaryotic regulatory systemsReviews... The book is recommended to advanced students and scientists dealing with life sciences, especially to microbiologists and molecular biologists Internatl Microbiol '...a useful monograph' Heredity '...It is a book that should be read and not merely used for reference...If you want to understand the main mechanisms of bacterial gene regulation and to appreciate their history, breadth and detail, read this book.' Micro Biology Today ... The book is recommended to advanced students and scientists dealing with life sciences, especially to microbiologists and molecular biologists Internatl Microbiol '...a useful monograph' Heredity '....It is a book that should be read and not merely used for reference....If you want to understand the main mechanisms of bacterial gene regulation and to appreciate their history, breadth and detail, read this book.' Micro Biology Today Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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