Pioneering Stem Cell/Gene Therapy Trials

Author:   Roger Bertolotti ,  Keiyo Ozawa ,  H. Kirk Hammond
Publisher:   Brill
Volume:   2
ISBN:  

9789067643948


Pages:   330
Publication Date:   15 October 2003
Format:   Hardback
Availability:   In Print   Availability explained
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Pioneering Stem Cell/Gene Therapy Trials


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Overview

The first unequivocal success for Gene Therapy was reported in April 2000 for X-SCID patients. Pioneering stem cell/gene therapy clinical trials are the focus of this book. Therapy successes such as the X-SCID trial and improved ADA-SCID ones are presented together with pioneering angio/vasculogenic clinical trials mediated either by transient gene therapy or emerging autologous stem cell transplantation. Highlights also include 1) promises of the breakthrough combination of stem cell- and transient gene-therapy, 2) gene therapy trials for neurodegenerative disease on non-human primates where long-term gene therapy might involve brain stem cells, and 3) the first clinical trial with non-invasive monitoring of therapeutic gene expression as a prospective conclusion. This volume will be of value and interest to researchers in this exciting field.

Full Product Details

Author:   Roger Bertolotti ,  Keiyo Ozawa ,  H. Kirk Hammond
Publisher:   Brill
Imprint:   VSP International Science Publishers
Volume:   2
Dimensions:   Width: 15.60cm , Height: 2.00cm , Length: 23.40cm
Weight:   0.344kg
ISBN:  

9789067643948


ISBN 10:   9067643947
Pages:   330
Publication Date:   15 October 2003
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Introduction; Stem cell-gene therapy: a breakthrough combination magnified by therapeutic stem cell homing; Inherited disease: stem cells and life-long therapeutic gene expression paradigm; Clinical gene therapy trials for ADA deficiency and other Immunodeficiencies; Regenerative cardiovascular medicine: transient gene therapy and autologous stem cell transplantation 1. Transient angiogenic/vasculogenic gene therapy clinical trials Vascular endothelial growth factor (VEGF) gene therapy for critical limb ischemia 2. Autologous stem cell therapy: clinical trials for cardiovascular Disease 3. Synergyzing stem cell* and gene-therapy for cardiovascular Regeneration; Neurodegenerative disease: long-term gene therapy and neural/stem cell targets; Non-invasive monitoring of clinical gene therapy trials

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Author Information

Roger Bertolotti, CNRS, Molecular Genetics, Department of Hepato-Gastroenterology, Faculty of Medicine, University of Nice-Sophia Antipolis, France. Keiyo Ozawa, Division of Hematology, Department of Medicine, and Division of Cell Transplantation and Transfusion, and Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical School, Japan. H. Kirk Hammond, Division of Cardiology, VA San Diego Healthcare System and University of California, San Diego School of Medicine, San Diego, California.

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