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Overview"2. The Translational Machinery ...5 Translation Initiation in Prokaryotes ...6 Translation Initiation in Eukaryotes ...8 14 Translation Elongation ...Translation Termination in Prokaryotes ...16 Translation Termination in Eukaryotes ...17 Error Correction in Translation ...18 A Structural Basis of Error Correction in Translation ...20 Ribosome Editing: A Failsafe Error Correction Mechanism ...22 Conclusions ...22 3. Errors During Elongation Can Cause Translational 29 Frameshifting ...Spontaneous Frameshifting Versus Programmed Frameshifting ...30 Spontaneous Frameshifts Can Be Induced at Specific Codons ...31 4. Programmed +1 Frameshifting ...41 The pifE Gene of E. coli ...41 Using the pifE System to Study General Frameshifting in E. coli ...46 Ty Retrotransposons in Yeast ...47 Frameshifting in Retrotransposon Ty1 Occurs by tRNA Slippage ...48 Frameshifting in Retrotransposon Ty3 Occurs by Out-of-Frame Binding of tRNA ...51 The Rat Ornithine Decarboxylase Antizyme Gene ...56 Summary ...62 5. Programmed -1 Frameshifting in Eukaryotes ...69 Programmed -1 Frameshifting in Eukaryotes ...69 -1 Frameshifting Occurs on a ""Slippery Heptamer"" ...71 The Simultaneous-Slippage Model ...7 2 of -1 Frameshifting by a Downstream Pseudoknot ...77 Stimulation Does the Pseudoknot Only Block Passage of the Ribosome? ...79 Not All Pseudoknots Which Cause Ribosomes to Pause Can Stimulate -1 Frameshifting ...84 Is There a Pseudoknot Recognizing Factor? ...88 Some Simultaneous-Slippage Sites Do Not Include a Stimulatory Pseudo knot ...91 Frameshifting Regulates a Morphogenetic Process ...92 6. Programmed -1 Frameshift Sites in Prokaryotes ...103 The dnaXGene: -1 Frameshifting Stimulated by Both Upstream and Downstream Elements ...103 Programmed -1 Frameshifts in Insertion Sequences Are Mechanistically Diverse ..." Full Product DetailsAuthor: Philip J. FarabaughPublisher: Chapman and Hall Imprint: Chapman and Hall Edition: 1997 ed. Dimensions: Width: 17.80cm , Height: 1.40cm , Length: 25.40cm Weight: 1.330kg ISBN: 9780412137518ISBN 10: 0412137518 Pages: 208 Publication Date: 15 March 1997 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1. Introduction.- 2. The Translational Machinery.- 3. Errors During Elongation Can Cause Translational Frameshifting.- 4. Programmed +1 Frameshifting.- 5. Programmed ?1 Frameshifting in Eukaryotes.- 6. Programmed ?1 Frameshift Sites in Prokaryotes.- 7. tRNA Hopping.- 8. Programmed Readthrough of Translational Termination Codons.- 9. Programmed Alternative Decoding as Programmed Translational Errors.- 10. Concluding Remarks.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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