Overview

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Full Product Details

Author:   Wen-Quan Zou ,  Pierluigi Gambetti
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2013 ed.
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   5.029kg
ISBN:  

9781461453048

ISBN 10:   1461453046
Pages:   242
Publication Date:   13 November 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1 Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek Paul Brown Chapter 2 The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein Glenn L. Millhauser Chapter 3 Role of Cellular Prion Protein in the Amyloid-ss Oligomer Pathophysiology of Alzheimer's Disease Adam C. Kaufman, Stephen M. Strittmatter Chapter 4 Cellular Prion Protein and Cancers Wei Xin, Man-sun Sy, Chaoyang Li Chapter 5 Insoluble Cellular Prion Protein Wen-Quan Zou Chapter 6 Protein Misfolding Cyclic Amplification Fabio Moda, Sandra Pritzkow, Claudio Soto Chapter 7 Cofactor Involvement in Prion Propagation Surachai Supattapone, Michael B. Miller Chapter 8 Prion Protein Conversion and Lipids Jiyan Ma Chapter 9 New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating Ilia V. Baskakov Chapter 10 Infectious and Pathogenic Forms of Prion Protein Emiliano Biasini, David A. Harris Chapter 11 Cellular Mechanisms of Propagation and Clearance Hermann M. Schatzl Chapter 12 Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains Jiri G. Safar Chapter 13 Modeling the Cell Biology of Prions Richard Rubenstein, Robert B. Petersen Chapter 14 Prion Strain Interference Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz Chapter 15 Introduction to Yeast and Fungal Prions Reed B. Wickner Chapter 16 Yeast Prions are Pathogenic, in-register Parallel Amyloids Reed B. Wickner, Herman K. Edskes, David A. Bateman, Amy C. Kelly, Anton Gorkovskiy

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