Overview

X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.

Full Product Details

Author:   Jan Drenth
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 3rd ed. 2007
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.534kg
ISBN:  

9781441922106

ISBN 10:   1441922105
Pages:   332
Publication Date:   29 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Crystallizing a Protein.- X-ray Sources and Detectors.- Crystals.- Theory of X-ray Diffraction by a Crystal.- Average Reflection Intensity and Distribution of Structure Factor Data.- Special Forms of the Structure Factor.- The Solution of the Phase Problem by the Isomorphous Replacement Method.- Phase Improvement.- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Configuration.- Molecular Replacement.- Direct Methods.- Laue Diffraction.- Refinement of the Model Structure.- The Combination of Phase Information.- Checking for Gross Errors and Estimating the Accuracy of the Structural Model.- Practical Protein Crystallization.

Reviews

From the reviews of the third edition: This book, Principles of Protein X-ray Crystallography, aims to satisfy nearly everyone; ... The volume is well organized ... . this is a solid book by an experienced protein crystallographer. It covers the full spectrum of subjects for a professional structural biologist. Specialized subjects are kept in separate chapters so the book can be parsed by those interested in the big picture of the method. ... it is probably the most definitive work that is currently available for structural biologists. (Jon Robertus, Journal of the American Chemical Society, Vol. 129 (17), 2007)

From the reviews of the third edition: This book, Principles of Protein X-ray Crystallography, aims to satisfy nearly everyone; ! The volume is well organized ! . this is a solid book by an experienced protein crystallographer. It covers the full spectrum of subjects for a professional structural biologist. Specialized subjects are kept in separate chapters so the book can be parsed by those interested in the big picture of the method. ! it is probably the most definitive work that is currently available for structural biologists. (Jon Robertus, Journal of the American Chemical Society, Vol. 129 (17), 2007)

Author Information

Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands. Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions