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Overview"""Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. "" Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic." Full Product DetailsAuthor: M. Filippi , G. ComiPublisher: Springer Verlag Imprint: Springer Verlag Edition: Softcover reprint of the original 1st ed. 2002 Dimensions: Width: 15.50cm , Height: 0.80cm , Length: 23.50cm Weight: 0.226kg ISBN: 9788847022362ISBN 10: 8847022363 Pages: 128 Publication Date: 06 March 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand We will order this item for you from a manufactured on demand supplier. Table of Contents1 — Observations from the Natural History Cohort of London, Ontario.- 2 — Pathology.- 3 — Immunology.- 4 — Neurophysiology.- 5 — Neuropsychology.- 6 — Overview of Treatment Trials: Early Baseline Clinical and MRI Data of the PROMiSe Trial.- 7 — Conventional MRI.- 8 — Magnetization Transfer and Diffusion Tensor Magnetic Resonance Imaging.- 9 — Proton Magnetic Resonance Spectroscopy.- 10 — Functional Magnetic Resonance Imaging.- Subjectlndex.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |