Overview

In this thorough and state-of-the-art book, top experts provide cutting edge techniques which greatly expand the depth and scope of classical invasive prenatal diagnosis. The book features a totally unique focus on novel non-invasive approaches for prenatal diagnosis. Following the Methods in Molecular Biologya series format, the chapters feature step-by-step laboratory protocols, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls.

Full Product Details

Author:   Sinuhe Hahn ,  Laird G. Jackson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2008
Volume:   444
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.534kg
ISBN:  

9781617377877

ISBN 10:   1617377872
Pages:   331
Publication Date:   19 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Invasive Approaches.- Spectral Karyotyping (SKY): Applications in Prenatal Diagnostics.- Characterization of Prenatally Assessed De Novo Small Supernumerary Marker Chromosomes by Molecular Cytogenetics.- Rapid Prenatal Aneuploidy Screening by Fluorescence In Situ Hybridization (FISH).- Application of Multi-PRINS to Simultaneously Identify Chromosomes 18, X, and Y in Prenatal Diagnosis.- Prenatal Diagnosis Using Array CGH.- Prenatal Detection of Chromosome Aneuploidy by Quantitative Fluorescence PCR.- Real-Time Quantitative PCR for the Detection of Fetal Aneuploidies.- MLPA for Prenatal Diagnosis of Commonly Occurring Aneuploidies.- MALDI-TOF Mass Spectrometry for Trisomy Detection.- Rapid Detection of Fetal Mendelian Disorders: Thalassemia and Sickle Cell Syndromes.- Rapid Detection of Fetal Mendalian Disorders: Tay-Sachs Disease.- Arrayed Primer Extension Reaction for Genotyping on Oligonucleotide Microarray.- A Fast Microelectronic Array for Screening and Prenatal Diagnosis of ?-Thalassemia.- Noninvasive Approaches.- RHD Genotyping from Maternal Plasma: Guidelines and Technical Challenges.- Isolation of Cell-Free DNA from Maternal Plasma Using Manual and Automated Systems.- Fetal DNA: Strategies for Optimal Recovery.- Quantification of Circulatory Fetal DNA in the Plasma of Pregnant Women.- Detection and Quantification of Fetal DNA in Maternal Plasma by Using LightCycler Technology.- Size Fractionation of Cell-Free DNA in Maternal Plasma and Its Application in Noninvasive Detection of Fetal Single Gene Point Mutations.- MALDI-TOF Mass Spectrometry for Analyzing Cell-Free Fetal DNA in Maternal Plasma.- Isolation of Cell-Free RNA from Maternal Plasma.- A Microarray Approach for Systematic Identification of Placental-Derived RNA Markers in Maternal Plasma.- A NovelMethod to Identify Syncytiotrophoblast-Derived RNA Products Representative of Trisomy 21 Placental RNA in Maternal Plasma.- Method for Extraction of High-Quantity and -Quality Cell-Free DNA from Amniotic Fluid.- Detection of New Screening Markers for Fetal Aneuploidies in Maternal Plasma: A Proteomic Approach.

Reviews

"From the reviews: ""This comprehensive book describes invasive and noninvasive techniques for diagnosing various chromosomal and genetic disorders prenatally. … the book was written for molecular biologists and those involved in research in the area of prenatal medicine. … has a consistent style to convey the information, making each chapter readable and relatable to the previous chapters. … as a compilation of techniques and a description of the situations in prenatal medicine in which each technique might be useful, this is an excellent and detailed resource."" (Gilad A. Gross, Doody’s Review Service, August, 2008)"

From the reviews: This comprehensive book describes invasive and noninvasive techniques for diagnosing various chromosomal and genetic disorders prenatally. ! the book was written for molecular biologists and those involved in research in the area of prenatal medicine. ! has a consistent style to convey the information, making each chapter readable and relatable to the previous chapters. ! as a compilation of techniques and a description of the situations in prenatal medicine in which each technique might be useful, this is an excellent and detailed resource. (Gilad A. Gross, Doody's Review Service, August, 2008)

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