Overview

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.  Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians. 

Full Product Details

Author:   Stephen H. Tsang ,  George M. Church
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Volume:   1016
Weight:   0.454kg
ISBN:  

9783319876672

ISBN 10:   3319876678
Pages:   178
Publication Date:   05 September 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part 1. Introduction to the CRISPR Revolution.- 1. Viral Vectors, Engineered Cells and the CRISPR Revolution.- 2.  Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing.- Part 2. CRISPR in Model Systems.-  3. From Reductionism to Holism: Toward a More Complete View of Development through Genome Engineering.- 4. Genome Engineering in Mice.- 5. Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors.- 6. From Prokaryotic Immune Systems to Plant Genome Editing Tools.- 7. Part 3. The Future of CRISPR.- 7. Using High-throughput Gene Editing to Identify Therapeutic Targets in the Noncoding Genome.- 8. CRISPR in the Retina: Evaluation of Future Potential.- 9. The Future of CRISPR Applications in the Lab, the Clinic and Society.

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Author Information

For years, Stephen Tsang has been culturing embryonic stem (ES) cells and created the first mouse model for a recessive form of retinitis pigmentosa by applying homologous recombination to ES cell technology. Two elements define his laboratory. First, by leveraging his genetics clinical practice, in which over 1000 retinal patients are cared for, he brings an array of clinical resources to his research, including stem cells and live imaging data. Second, he and his students are recognized authorities in a broad array of state-of-the-art technologies. Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the Genome session during the 65th American Society of Human Genetics Annual Meeting.

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