Overview

Power Analysis of Trials with Multilevel Data covers using power and sample size calculations to design trials that involve nested data structures. The book gives a thorough overview of power analysis that details terminology and notation, outlines key concepts of statistical power and power analysis, and explains why they are necessary in trial design. It guides you in performing power calculations with hierarchical data, which enables more effective trial design. The authors are leading experts in the field who recognize that power analysis has attracted attention from applied statisticians in social, behavioral, medical, and health science. Their book supplies formulae that allow statisticians and researchers in these fields to perform calculations that enable them to plan cost-efficient trials. The formulae can also be applied to other sciences. Using power analysis in trial design is increasingly important in a scientific community where experimentation is often expensive, competition for funding among researchers is intense, and agencies that finance research require proposals to give thorough justification for funding. This handbook shows how power analysis shapes trial designs that have high statistical power and low cost, using real-life examples. The book covers multiple types of trials, including cluster randomized trials, multisite trials, individually randomized group treatment trials, and longitudinal intervention studies. It also offers insight on choosing which trial is best suited to a given project. Power Analysis of Trials with Multilevel Data helps you craft an optimal research design and anticipate the necessary sample size of data to collect to give your research maximum effectiveness and efficiency.

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Reviews

I enjoyed reviewing the new CRC Press/Chapman Hall book entitled Power Analysis of Trials with Multilevel Data, by Mirjam Moerbeek and Steven Teerenstra. This book addresses a critical need in the scientific community for a well-organized, easily accessible guide to performing power analysis and computing required sample sizes for randomized trials embedded in multilevel study designs, where observations of interest are nested within higher level units (e.g. patients within clinics or repeated measures on participants). ... This book effectively compiles all the published literature on this specialized topic, putting it in one place for researchers who design these types of studies and could benefit from a concise and practical resource on this important aspect of study design. The two Dutch authors are experts in this area and are very well-equipped to provide more general education and practical advice on this topic. Multilevel study designs in which power analysis methods for independent observations do not apply are quite common, but no prior books have attempted to organize all the possible power analysis approaches for these types of studies into a single reference. ... In sum, this will be a very useful book for researchers, statisticians, and consultants responsible for designing various types of randomized trials in multilevel settings. My minor quibbles are far outweighed by the important contributions that this single resource on power analysis in multilevel designs will make to the scientific community. --Brady T. West, University of Michigan, Biometrical Journal, May 2017 ...the appearance of the book, Power Analysis of Trials with Multilevel Data, is well timed...Another nice feature of the book is the example power analyses that conclude most chapters (and sometimes appear earlier in chapters as well). The authors have done a very good job finding articles in the literature that use a particular design, extracting relevant parameters from those articles, and then illustrating how to use those parameters to plan a replication study...I think this book deserves a place on the bookshelf of both researchers who plan experimental studies and statisticians who advise them. --Christopher H. Rhoads, University of Connecticut, The American Statistician, November 2016

Author Information

Mirjam Moerbeek is an associate professor at Utrecht University, the Netherlands. She obtained her master’s degree (cum laude) in biometrics from Wageningen Agricultural University in 1996 and her PhD in applied statistics from Maastricht University in 2000. She has received prestigious research grants from the Netherlands’ Organisation for Scientific Research (NWO) as well as grants to hire PhD students. Her research interests are statistical power analysis and optimal experimental design, especially for hierarchical and survival data. She was involved in organizing a colloquium and class on cost-efficient and optimal designs for the Royal Netherlands Academy of Arts and Sciences (KNAW) and is a joint organizer of the biennial International Conference on Multilevel Analysis. Steven Teerenstra received his MSc and PhD in mathematics at Radboud University in 1996 and 2004, respectively, as well as his MSc in theoretical physics in 2006. He is currently a biostatistician at Radboud University Nijmegen Medical Center, involved in research, consultation and conduct of cluster randomized trials. He is appointed assessor of statistics and methodology at the Dutch Medicines Evaluation Board and a member of the Biostatistics Working Party at the European Medicines Agency.

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