Overview

This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.

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9783319823492

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Christine Vauthier is Director of Research at the CNRS (Centre National de la Recherche Scientifique) at the Institut Galien Paris Sud, Université Paris-Sud, France. Dr. Vauthier also serves as an editor for the journal Pharmaceutical Research. She received her Ph. D. in polymer chemistry from the University Louis Pasteur at Strasbourg, France.  She then joined the University of Paris South, Faculty of Pharmacy as a research assistant. The focus of her research is about understanding the influence of the physicochemical characteristics of nanomedicines and their interactions with biological systems when the nanomedicines are intended to improve drug delivery after mucosal or intravenous administration. She is author and co-author of more than 120 research papers as well as over 20 review papers and book chapters on nanoparticle preparation, characterization methods, and on the application of nanoparticles as drug delivery systems. Dr. Vauthier has spoken at numerous conferences and has presented over 100 communications.  Prof. Gilles Ponchel is full professor at the University of Paris-South where he teaches Pharmaceutical Technology and Biopharmacy. He leads a multidisciplinary research team that belongs to the Institut Galien Université Paris-Sud and specializes in the field of drug delivery. The aim of the team is to conceive and to develop innovative drug delivery systems that can improve the crossing of active drugs through physico-chemical and biological barriers. His main research interests are: (i) the development and the evaluation of bioadhesive delivery systems and (ii) the conception of pharmaceutically acceptable nanomedecines, mainly multifunctionalized nanoparticles prepared from tailored polymers, polypeptides, cyclodextrins, etc. for optimizing their biodistribution in the context of drug targeting applications. Prof. Ponchel is the author of over 130 research papers, more than 170 communications, more than50 invited lectures. He has been co-author and contributor to books and many book chapters.

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