Overview

Pharmacogenomics may be one of the most important current discoveries in medicine and is the study of the role of the genome in drug response. The name reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated through a drug's biological targets).The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that pharmaceutical drug treatments can deviate from what is dubbed as the one-dose-fits-all approach. Pharmacogenomics also attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient's genes, the functionality of these genes, and how this may affect the efficacy of the patient's current or future treatments. Such approaches promise the advent of precision medicine and even personalized medicine, in which drugs and drug combinations are optimized for narrow subsets of patients or even for each individual's unique genetic makeup.This book is designed to be a state of the art, superb academic reference work and provide an overview of the topic and give the reader a structured knowledge to familiarize yourself with the topic at the most affordable price possible.The accuracy and knowledge is of an international viewpoint as the edited articles represent the inputs of many knowledgeable individuals and some of the most current knowledge on the topic, based on the date of publication.

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9781548521578

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The editor has degrees in Engineering Physics, Biomedical Engineering & Nuclear Engineering from the University of Michigan and is an Engineer & Former Intelligence Officer for the CIA & US Intelligence Community and was President & Founder of an award-winning Defense Contracting Company. He has authored several books, edited numerous other books and has written many Technical, Classified & Unclassified papers, Articles & Essays. He has also been a Contributing Author for The International Encyclopedia on Intelligence and Counter-Intelligence and written several award-winning software manuals that have been sold in more than a dozen countries. He has appeared in Marquis Who's Who in the World & Who's Who in Science & Engineering and continues to edit and write.

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