Overview

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level. 

Full Product Details

Author:   Kim Lewis
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Weight:   0.629kg
ISBN:  

9783030252403

ISBN 10:   303025240
Pages:   295
Publication Date:   26 November 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Evolution under antibiotic treatments: interplay between antibiotic persistence, tolerance and resistance.- 2. Antibiotic persisters and relapsing Salmonella enterica infections.- 3. The Biology of Persister Cells in E. coli.- 4. Persister Formation and Antibiotic Tolerance of Chronic Infections.- 5. Persister formation driven by TisB-dependent membrane depolarization.- 6. Toxin-antitoxin systems and persistence.- 7. Nutrient depletion and bacterial persistence.- 8. Genetic determinants of persistence in Escherichia coli.- 9. Persister resuscitation.- 10. Host-pathogen interactions influencing Mycobacterium tuberculosis persistence and drug tolerance.- 11. Drug susceptibility of individual mycobacterial cells.- 12. Antimicrobial drug discovery against persisters.  

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Professor Kim Lewis, Northeastern University Boston, Massachusetts, USA

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