Overview

Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications. Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including: * Properties of peptide scaffolds in solution and on solid substrates * Nanostructures, peptide assembly, and peptide nanostructure design * Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids * Functionalization of carbon nanotubes with peptides * Adsorption of peptides on metal and oxide surfaces * Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.

Full Product Details

Author:   Carlos Aleman ,  Alberto Bianco ,  Mariano Venanzi
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 15.00cm , Height: 1.50cm , Length: 25.00cm
Weight:   0.666kg
ISBN:  

9781118592403

ISBN 10:   1118592409
Pages:   496
Publication Date:   29 March 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Digital
Publisher's Status:   Active
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

Preface xiii List of Contributors xvii Part I Fundamentals of Peptide Materials 1 1 Physics of Peptide Nanostructures and Their Nanotechnology Applications 3 Nadav Amdursky, Peter Beker and Gil Rosenman 1.1 Introduction to Peptide Nanotubes 4 1.2 Optical Properties and Quantum Confinement of FF-based Nanostructures 8 1.3 Odd-Tensor Related Physical Properties 13 1.4 Thermal Induced Phase Transition in Peptide Nanotubes 17 1.5 Deposition Techniques of PNT 22 1.6 Applications of PNTs 29 1.7 Conclusion 32 References 33 2 Chemistry of Peptide Materials: Synthetic Aspects and 3D Structural Studies 39 Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio Toniolo 2.1 Introduction 40 2.2 Synthesis of Difficult Peptide Sequences 40 2.3 Peptide (Amide) Bond 43 2.4 Peptide Torsion Angles 44 2.5 Peptide Secondary Structures 46 References 58 3 Conformational Aspects and Molecular Dynamics Simulations of Peptide Hybrid Materials: From Methods and Concepts to Applications 65 Carlos Aleman, Oscar Bertran, Jordi Casanovas, Juan Torras, Guillermo Revilla-Lopez and David Zanuy 3.1 Computational Chemistry 66 3.2 Quantum Mechanical Calculations: Concepts 67 3.3 Quantum Mechanical Calculations on Hybrid Peptide Materials: Some Examples 72 3.4 NCAD: An Information Management System of Quantum Mechanical Calculations on Noncoded Amino Acids for Peptide Design 74 3.5 Molecular Mechanics Calculations: Concepts 77 3.6 Molecular Dynamics Simulations on Peptides 85 3.7 Summary 97 Acknowledgements 97 References 98 4 Peptronics: Peptide Materials for Electron Transfer 105 Emanuela Gatto and Mariano Venanzi 4.1 Introduction 106 4.2 Electron Transfer through Peptide Scaffolds in Solution 107 4.3 Electron Transfer through Supported Peptide Matrices 121 4.4 Conclusions and Perspectives 143 Acknowledgements 143 References 144 Part II Peptide Nanostructures 149 5 Molecular Architecture with Peptide Assembling for Nanomaterials 151 Shunsaku Kimura and Motoki Ueda 5.1 Introduction 151 5.2 Peptide Vesicles 152 5.3 Peptide Building Blocks 157 5.4 Peptide Architecture 159 5.5 Function of Peptide Assemblies 161 5.6 Tumor Imaging with Peptide Nanocarrier 163 5.7 Perspectives 167 References 168 6 Principles of Shape-Driven Nanostructure Design via Self-Assembly of Protein Building Blocks 171 Idit Buch, Chung-Jung Tsai, Carlos Aleman and Ruth Nussinov 6.1 Introduction 172 6.2 Self-Assembly into Preferred Shapes 172 6.3 Designing Protein Nanotubes 180 6.4 Summary and Outlook 185 Acknowledgements 186 References 186 7 Peptide-Based Soft Spherical Structures 191 K. Vijaya Krishna, Nidhi Gour and Sandeep Verma 7.1 Introduction 191 7.2 Short Peptide Sequences 192 7.3 Amphiphilic Peptides 200 7.4 Peptide Polymer Hybrids 205 7.5 Future Outlook 209 References 211 Part III Peptide Conjugates and Hybrid Materials 217 8 Peptide-Based Carbon Nanotube Dispersal Agents 219 Anton S. Klimenko and Gregg R. Dieckmann 8.1 Introduction 220 8.2 -Helical Surfactant Peptides 222 8.3 -Strand Surfactant-Like Peptides 229 8.4 Extended Peptides 231 8.5 Amorphous Peptides 233 8.6 Cyclic Peptides 234 8.7 Summary and Outlook 237 Acknowledgements 239 References 239 9 Nanosized Vectors for Transfection Assembled from Peptides and Nucleic Acids 247 Burkhard Bechinger 9.1 Introduction 248 9.2 Condensation of Nucleic Acids by Cationic Peptides and Other Macromolecules 250 9.3 The Size and Shape of Transfection Complexes 251 9.4 Cellular Targeting by Specific Ligands 252 9.5 Enhancing the Cellular Uptake of Nanocomplexes 252 9.6 Assuring Endosomal Escape 253 9.7 A Family of Multifunctional Peptide Sequences 255 9.8 Delivery to the Nucleus and Other Intracellular Compartments 257 9.9 Combining Different Functionalities into Complex Nanovectors 257 Acknowledgements 259 References 259 10 Properties of Disubstituted Ferrocene Peptide Conjugates: Design and Applications 265 Sanela Martiae, Samaneh Beheshti and Heinz-Bernhard Kraatz 10.1 Introduction 266 10.2 Structural Considerations and Properties 266 10.3 Fc Peptides to Probe Interactions 274 10.4 Conclusions 283 References 284 11 Mechanisms of Adsorption of Short Peptides on Metal and Oxide Surfaces 289 Vincent Humblot, Jessem Landoulsi and Claire-Marie Pradier 11.1 Introduction 290 11.2 Why Studying the Interaction of Short Peptides with Solid Surfaces? 291 11.3 Metal and Oxide Surfaces 292 11.4 Factors Influencing Peptide Adsorption 293 11.5 Adsorption at the Solid/Gas interface 295 11.6 Adsorption at the Solid/Liquid Interface 303 11.7 Conclusions and Guidelines for the Future 307 References 308 Part IV Applications of Peptide Materials 313 12 Bioactive Rosette Nanotubes for Bone Tissue Engineering and Drug Delivery 315 Rachel L. Beingessner, Alaaeddin Alsbaiee, Baljit Singh, Thomas J. Webster and Hicham Fenniri 12.1 Introduction 316 12.2 Rosette Nanotubes (RNTs) 317 12.3 Applications of RNTs in Bone Tissue Engineering 328 12.4 RNTs for Drug Delivery 340 12.5 Conclusions 349 References 350 13 Peptide Secondary Structures as Molecular Switches 359 Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio Toniolo 13.1 Introduction 360 13.2 Classical Secondary Structures Switches 360 13.3 Recently Discovered Secondary Structure Switches 365 13.4 Conclusions 376 References 378 14 Peptide Nanostructured Conjugates for Therapeutics: The Example of P140 Peptide for the Treatment of Systemic Lupus Erythematosus 385 Yves Frere, Louis Danicher and Sylviane Muller 14.1 Introduction 386 14.2 Noninvasive Routes of Peptide Administration 387 14.3 Encapsulation of Peptides and Proteins for Oral Delivery 390 14.4 P140 Peptide Nanostructured Complex for the Treatment of Systemic Lupus Erythematosus 399 14.5 General Comments 412 Acknowledgements 412 References 412 15 Identification and Application of Polymer-Binding Peptides 417 Toshiki Sawada and Takeshi Serizawa 15.1 Introduction 417 15.2 Biological Identification of Material-Binding Peptides 419 15.3 Recognition of Polymer Stereoregularity by Peptides 421 15.4 Recognition of Other Polymer Nanostructures by Peptides 424 15.5 Applications of Polymer-Binding Peptides 426 15.6 Summary 428 References 428 Index 435

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Carlos Aleman, Universitat Politecnica de Catalunya, Spain Alberto Bianco, CNRS, Laboratoire d Immunopathologie et Chimie Therapeutique, France Mariano Venanzi, University of Rome Tor Vergata, Italy

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