Overview

Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach.  This book gives the reader an overview on the design rules for de novo self-assembling peptide and reviews the diverse range of bioinspired peptide nanostructures such as β-sheet and β-hairpin, α-helical and coiled coil, self-assembling short peptides and peptidomimetics, collagen-based and elastin-like peptides, silk peptides, peptide amphiphiles, peptides co-polymers and others. The book also covers the wide variety of responsive and functional biomaterials that have been innovated based on those nanostructures for various applications ranging from tissue engineering, therapeutics and drug delivery to antimicrobial nanomaterials and biosensors. Finally, the book also discusses the peptide bionanomaterials global market and the future of the emerging industry. Chapter “Characterization of Peptide-Based Nanomaterials” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Full Product Details

Author:   Mohamed A. Elsawy
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2023 ed.
ISBN:  

9783031293627

ISBN 10:   3031293622
Pages:   555
Publication Date:   31 August 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1: Design Rules for De Novo Self-Assembling Peptide Nanostructures.- Chapter 2: β-Sheet and β-Hairpin Peptide Nanomaterials.- Chapter 3: α-Helix and Coiled-Coil Peptide Nanomaterials.- Chapter 4: Ultra-Short Peptide Nanomaterials.- Chapter 5: Peptide Amphiphile Nanomaterials.- Chapter 6: Polypeptide-Based Multicomponent Materials: From Design to Applications.- Chapter 7: Chirality in Peptide Self-Assembly and Aggregation.- Chapter 8: Characterization of Peptide-Based Nanomaterials.- Chapter 9: In-Silico Prediction of Peptide Self-Assembly into Nanostructures.- Chapter 10: Advanced Manufacturing of Peptide Nanomaterials.- Chapter 11: Self-Assembling Peptide Hydrogels as Extracellular Matrix Mimicking Scaffolds for Tissue Regeneration in Chronic-Degenerative Diseases.- Chapter 12: Peptide Nanostructured Materials as Drug Delivery Carriers.- Chapter 13: Peptide and Protein Emulsifiers.- Chapter 14: Antimicrobial Peptide Nanomaterials.- Chapter 15: Multifunctional Peptide Biointerfaces.- Chapter 16: Peptide Bionanomaterials Global Market: The Future of Emerging Industry.

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Author Information

Dr Mohamed Elsawy is a Senior Lecturer in Pharmaceutical Sciences at the Leicester School of Pharmacy, De Montfort University and the team leader of the Peptide BioNanomaterials Group (PBNG). He obtained his PhD from School of Pharmacy at Queen’s University of Belfast in 2012 followed by a short-term fellowship at University of Bordeaux in 2013 and an EPSRC funded postdoctoral training in University of Manchester between 2014-2017. In 2017, he was appointed a lectureship in Pharmaceutics at the School of Pharmacy and Biomedical Sciences, University of Central Lancashire, then in 2020 he moved to the Leicester Institute for Pharmaceutical Innovation at Leicester School of Pharmacy, where he currently works. Dr Elsawy's research focus on understanding the fundamentals of peptide self-assembly into bio-inspired structures for the design of stable and responsive functional bionanomaterials for various biomedical and pharmaceutical applications, with particular interest in drug delivery and tissue engineering. Together with the rational bottom-up molecular design of peptide nanostructures, his group is currently working towards exploitation of various smart manufacturing technologies for the controlled design and fabrication of these materials.

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