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OverviewIn her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs. Full Product DetailsAuthor: Sara BobonePublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 2014 ed. Dimensions: Width: 15.50cm , Height: 1.10cm , Length: 23.50cm Weight: 3.613kg ISBN: 9783319064338ISBN 10: 3319064339 Pages: 140 Publication Date: 24 June 2014 Audience: Professional and scholarly , College/higher education , Professional & Vocational , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsOverview.- Antimicrobial Peptides: Mechanism of Action, Selectivity and Biological Activity.- Introduction.- Techniques.- Materials and Methods.- Results and Discussion.- Hydrogel Nanoparticles for Enzyme-Based Therapies.- Introduction.- Materials and Methods.- Results and Discussion.- Concluding Remarks.ReviewsAuthor Information"I received my M.Sc. Degree in Chemistry magna cum laude from the University of Rome ""Sapienza"". After the degree, I moved to Tor Vergata, where I won a fellowship for PhD students in Chemical Sciences, under the supervision of Prof. L. Stella. I defended my thesis in 2013 and then continued my work as a postdoctoral fellow. The thesis was awarded the 2012-2013 ""Premio Semerano"" by the Italian Chemical Society, as the best Italian PhD Physical Chemistry Thesis. The thesis work led to the publication of 7 papers on international journals and to the participation to 13 international and national conferences." Tab Content 6Author Website:Countries AvailableAll regions |
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