Overview

Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

Full Product Details

Author:   Sajal Chakraborti (Professor, Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, India) ,  Srijit Das, PhD (Professor of Anatomy, Department of Human and Clinical Anatomy, Sultan Qaboos University, Oman) ,  Cheorl-Ho Kim (Professor and Chair, Department of Biological Sciences, College of Science, Sungkyunkwan University and Samsung Advanced Institute of Health Science and Technology (SAIHST), Korea)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780443300981

ISBN 10:   0443300984
Pages:   648
Publication Date:   01 November 2024
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

Section I: General Aspects 1. Pathophysiological aspects of calpains in cancer 2. Mitochondrial proteases in cancer development and progression 3. Proteases in Head and Neck Cancer 4. Matrix metalloproteases and uveal melanomas 5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects 6. Radiotherapy, proteases and gastric cancer: a complex interplay 7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma 8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy 9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer 10. Ubiquitin –specific protease 3,7 in bone cancer and squamous cell carcinoma 11. Serine protease: structure, classification, mechanism and role in breast cancer Section II: Proteases as Diagnostics and Prognostics Biomarkers 12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer 13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer 14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis 15. Cathepsins as a diagnostic and prognostic marker in Oral cancer 16. Role of Kallikreins in Prostate Cancer 17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer 18. The role of acetylcholinesterase in cancer development and possible therapeutic applications 19. Therapeutics of animal derived compounds in proteases induced cancer 20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis Section III: Proteases, Chemoresistance and Cancer 21. Serine proteases, chemoresistance and cancer 22. Cathepsins, chemoresistance and cancer 23. ix metalloproteases, chemoresistance and cancer 24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer 25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer 26. Role of the proteasome in the development of chemoresistance in multiple myeloma 27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer 28. Proteases, chemoresistance and cancer 29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance Section IV: Other Aspects 30. Matrix metalloproteases-targeting low molecular weight compound 31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials. 32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials 33. Side effects of synthetic protease inhibitors used in gynecology cancers 34. Role of synthetic compounds with protease inhibitory activity in breast cancer 35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors

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Author Information

Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 35 years teaching and independent research experience in Biochemistry, Molecular Physiology and Cell Biology. He has published over 110 original research articles, dozens of review articles and book chapters, and also edited twelve books. Dr. Srijit Das is currently Professor of Anatomy at the Sultan Quaboos University in Oman. He has decades teaching experience in Anatomy including Embryology, Histology, Gross Anatomy, Neuroanatomy, Radiological Anatomy, Clinical Anatomy, and Surface Anatomy. He is member of World Association of Medical Editors. He published 500 articles in world-renowned journals, published 5 books and is editorial board member of numerous globally respected journals. Prof/Dr Cheorl-Ho Kim has received his MS and PhD in The University of Tokyo during the period of 1985-1990. Currently, since 2006 he is professor and chair of Department of Biological Sciences, College of Science, Sungkyunkwan University and Samsung Advanced Institute of Health Science and Technology (SAIHST), Korea. He has successfully completed his Administrative responsibilities as Genome Program Head, Korea Research Institute of Bioscience and Biotechnology on 1990-1996 and Chairman, Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University during 1996-2006. His research has included the molecular biology of gene expression, ER-Golgi glycosyltransferases, oncogenesis, cancer metastasis and angiogenesis. He has authored more than 350 research articles/books with H-index 66. He is a member of International Scientific Advisory Board Member, International Symposium for Glycosyltransferases (GlycoT 2006), IUBMB symposium, Tsukuba and International Symposium for Glycosyltransferases (GlycoT 2008), Emory University, GA, USA, 2010 Tokai University GlycoResearch Center and 2015 Visiting Professor, The Ohio State University

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