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OverviewMycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts. Full Product DetailsAuthor: Jean Pieters , John D. McKinneyPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: Softcover reprint of the original 1st ed. 2013 Volume: 374 Dimensions: Width: 15.50cm , Height: 1.40cm , Length: 23.50cm Weight: 3.927kg ISBN: 9783662521427ISBN 10: 3662521423 Pages: 245 Publication Date: 23 August 2016 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsGenetic Diversity in Mycobacterium tuberculosis Sebastien Gagneux DNA Metabolism in Mycobacterial Pathogenesis Digby F. Warner, Tone Tønjum and Valerie Mizrahi Molecular Biology of Drug Resistance in Mycobacterium tuberculosis Tasha Smith, Kerstin A. Wolff, and Liem Nguyen Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan Getting Across the Cell Envelope: Mycobacterial Protein Secretion Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria Giulia Manina and John D. McKinney Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes Sabine Ehrt and Kyu Rhee Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters Host-Pathogen Interactions During Mycobacterium tuberculosis Infections Sarah Stanley and Jeffery S. CoxReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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