Overview

From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

Full Product Details

Author:   Juan Domínguez-Bendala
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2009 ed.
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.910kg
ISBN:  

9781607611318

ISBN 10:   1607611317
Pages:   154
Publication Date:   01 July 2009
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1: Preface. Importance of the subject in the context of type I diabetes. 2: The pancreas. 3: Pancreatic development. 4: Pancreatic regeneration. 1. Models of regeneration. 2. Stem cells vs. beta cell replication. 5: Stem cell differentiation: general approaches. 1. Recapitulation of pancreatic development. 2. Signal-driven strategies. 3. Gene transfer and protein transduction. 4. Physiological variables. 6: Embryonic stem cells and pancreatic differentiation. 7: Adult stem cells and pancreatic differentiation. 1. Bone marrow. 2. Umbilical cord. 3. Ductal and acinar cells. 4. Mesenchymal stem cells and de-differentiation. 8: Transdifferentiation. 9: Remaining challenges and clinical perspectives.

Reviews

From the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ! of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ! With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)

From the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ! of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ! With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)

From the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ... of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ... With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)

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