Free Delivery Over $100
|
|
|||
|
||||
OverviewParkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease. Full Product DetailsAuthor: Prof. Rodrigo Franco (University of Nebraska-Lincoln, USA) , Prof. Jonathan A Doorn (University of Iowa, USA) , Prof. Jean-Christophe Rochet (Purdue University, USA) , Diana AndersonPublisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Volume: Volume 34 Weight: 0.968kg ISBN: 9781782621881ISBN 10: 1782621881 Pages: 536 Publication Date: 25 July 2017 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsParkinson’s Disease: Pathogenesis and Etiology; Oxidative Stress and Redox Signalling in the Parkinsonian Brain; Mitochondrial Dysfunction in Parkinson’s Disease; Catecholamine Metabolism and the Generation of Reactive Aldehydes; Dopamine Oxidation and Parkinson's Disease; GSH and Thiol Redox Signalling; Nitric Oxide Signalling and Inflammation in Parkinson’s Disease; Redox Signalling and Dopaminergic Cell Death/Survival; Iron Metabolism and Parkinson's Disease; Protein Oxidation, Quality Control and Degradation Pathways; At the Intersection between Mitochondrial Dysfunction and Lysosomal Autophagy; Genes, Environment and Aging; Biomarkers of Oxidative Stress; Dietary Factors in Parkinson’s Disease; Antioxidants and Redox-basedTherapeuticsReviewsThe book should be of interest to all individuals who are interested in PD. With a comprehensive and integrated view on the biology of PD, the Editors and Authors of the book are likely to be instrumental in stimulating a deeper understanding and promoting renewed collaborations on this multifaceted topic, leading to improved understanding of PD. -- Michael Aschner Research into the role of oxidative stress and redox signaling in Parkinson's disease (PD) has exploded. A PubMed search (January 8, 2018) identifies 4972 scholarly papers on this topic. Indeed, these are exciting times both for researchers, PD patients and their families. As the human genome has been sequenced and many disease mysteries are unraveled, exciting advances in research on PD have been achieved. Of particular interest in understanding the clinical picture of PD has been the relationship between oxidative stress and the pathophysiology of PD. The Book contains 14 chapters, addressing the topic, research strategies and models aimed at delineating molecular mechanisms of the disease. The typeface is easy to read and the visuals are of great quality. While multi-authored, I generally found all chapters to be up-to-date, providing authoritative reviews of epidemiology, pathology, and neurochemistry. The writing is generally succinct, with discussions pertinent to the topic at hand. The book should be of interest to all individuals who are interested in PD. The Editors should be commended for their efforts to produce a comprehensive, yet easy-to-follow authoritative book on current knowledge in this ever-growing field on PD. The book is successful in bridging basic research with clinical, epidemiological, regulatory and translational research, conveying both an introductory understanding and the latest development in the field. Utmost, it seems to be designed to serve both the novice student and the expert scientist and physician. With a comprehensive and integrated view on the biology of PD, the Editors and Authors the book are likely to be instrumental in stimulating a deeper understanding and promoting renewed collaborations on this multifaceted topic, leading to improved understanding of PD. -- Michael Aschner Author InformationDr Franco is an Assistant Professor of Neuroscience at the Redox Biology Center, University of Nebraska-Lincoln. Prior to this position, he was post-doctoral fellow at the National Institute of Environmental Health Sciences, USA. His research interests include the role of oxidative stress and redox signaling in the regulation of cell death pathways, and in neuronal cell death associated with neurological disorders. He has been awarded the Layman Award and the SIGMA XI Outstanding Young Scientist Award. Dr Doorn is an Associate Professor of Medicinal and Natural Products Chemistry at the University of Iowa, College of Pharmacy. Before this, he was a post-doctoral fellow at the University of Colorado Health Sciences Center, Depts. of Pharmaceutical Sciences and Pharmacology, USA. His postdoctoral work involved studying the role of lipid peroxidation products and protein carbonylation in alcoholic liver disease. Dr Doorn received his Ph.D. from the University of Michigan, School of Public Health, Toxicology Program. Dr Rochet is an associate professor in the Department of Medicinal Chemistry and Molecular Pharmacology (College of Pharmacy) at Purdue University. Before his arrival at Purdue, Dr Rochet received his PhD degree at the University of Alberta in Biochemistry in 1998 and then worked as a post-doctoral fellow studying mechanisms of alpha-synuclein self-assembly in Parkinson’s disease in the laboratory of Dr. Peter Lansbury at Harvard Medical School. Dr.Rochet’s research group has a long-standing interest in Parkinson’s disease. Tab Content 6Author Website:Countries AvailableAll regions |
||||
