Overview

This book aims to serve as a source of information for cutaneous biologists, dermatologists and biomedical scientists interested in free radicals and reactive oxygen species and their role in skin pathology. It covers all aspects of oxidative stress, including its importance in basic pathologic processes, as well as in skin diseases, dermatopharmacology and dermatotoxicology. A large data base of references is also provided. In the introduction, the physicochemical properties and production and target sites of reactive oxidants in the skin are discussed. The antioxidant systems of the skin are then described, and the participation of oxidants and antioxidants in basic pathophysiologic events is analyzed. Finally, specific aspects of oxidative injury in selected skin diseases, pharmacology and toxicology are investigated. The book deals in detail with many areas of cutaneous biology and clinical dermatology from the perspective of a free radical scientist and physician, and should serve as a cornerstone in this rapidly changing area of cutaneous biology research.

Full Product Details

Author:   Jurgen Fuchs
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Weight:   0.705kg
ISBN:  

9783540543558

ISBN 10:   3540543554
Pages:   372
Publication Date:   16 July 1992
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

1 History of a Concept.- 2 The Skin and Oxidative Stress.- A. Introduction.- I. Skin and Environmental Stress.- II. Oxidative Stress.- III. Skin as a Target Organ of Oxidative Injury.- B. Biological Oxidants.- I. Superoxide Anion Radical.- II. Hydrogen Peroxide.- III. Hydroxyl Radical.- IV. Singlet Oxygen.- V. Transition Metals.- VI. Radical Chelates.- VII. Hydroperoxides and Lipid Radicals.- VIII. Thiyl Radicals.- C. Production Sites of Reactive Oxidants in Skin.- I. Plasma Membrane.- II. Mitochondria.- III. Microsomes.- IV. Peroxisomes.- V. Cytosol.- D. Targets of Reactive Oxidants in Skin.- I. Lipids.- 1. Skin Lipid Composition.- 2. Lipid Peroxidation in Skin.- II. Proteins.- 1. Collagen.- 2. Proteases and Antiproteases.- 3. Amyloid.- 4. Amino Acid Racemization.- III. Carbohydrates.- IV. Nucleic Acids.- E. The Antioxidant System of the Skin.- I. Superoxide Dismutase.- II. Catalase.- III. Peroxidases.- IV. The Enzymic Glutathione System.- V. Thioredoxin Reductase System.- VI. Lipoamide System.- VII. NADPH Ubiquinone Reductase.- VIII. Nonenzymic Protein Antioxidants.- IX. Hydrophilic Antioxidants.- 1. Thiols.- 2. Ascorbate.- 3. Urate.- X. Lipophilic Antioxidants.- 1. Tocopherol.- 2. Vitamin A and Carotenoids.- 3. Ubiquinols/Ubiquinones.- 4. Bilirubin.- XI. Antioxidant Capacity of Skin.- 1. Regulation of the Skin Antioxidant Potential.- F. Biological Models for Studying Oxygen Toxicity.- I. Exercise Training.- II. Hyperbaric Oxygen Treatment.- 3 Reactive Oxidants and Antioxidants in Skin Pathophysiology.- A. Electromagnetic Radiation.- I. Ionizing Radiation.- 1. Formation of Reactive Species.- 2. Skin Damage.- 3. Ionizing Radiation and Lipid Peroxidation.- 4. Oxygen as a Radiation Sensitizer.- 5. Skin Radioprotection by Antioxidants.- II. Nonionizing Radiation.- 1. Formation of Reactive Oxidants by Ultraviolet Light.- 2. Ultraviolet-Light-Induced Skin Damage.- 3. Photoprotection by Antioxidants.- 4. Ultraviolet Light Effects on Skin Antioxidants.- 5. Infrared Radiation.- 6. Ultrasound.- III. Photosensitization.- 1. Endogenous Photosensitizers.- 2. Exogenous Photosensitizers.- IV. Photoaging.- V. Photocarcinogenesis.- 1. Photocarcinogenesis and Lipid Peroxidation.- 2. Photocarcinogenesis and Antioxidants.- VI. Photoimmunology.- VII. Skin Diseases with Abnormal Reactions to Light.- 1. Lupus Erythematosus.- 2. Diseases with Increased Cellular Susceptibility.- B. Mechanical and Thermal Skin Trauma.- I. Wound Healing.- II. Skin Burns.- C. Skin Ischemia.- I. Acute Skin Response to Ischemia.- II. Hematoma and Venous Ulcers.- III. Skin Ischemia after Burn/Frostbite.- D. Microbial Skin Diseases.- I. Autotoxicity.- E. Skin Aging.- I. Collagen.- II. Elastin.- III. Glycosaminoglycans.- IV. Lipid Peroxidation.- V. Fluorescent Pigments.- VI. Amyloid.- VII. Antioxidants.- F. Skin Immunology.- G. Skin Inflammation.- I. Phagocytes.- 1. Neutrophil Granulocytes.- 2. Eosinophil Granulocytes.- 3. Macrophages.- 4. Reactive Oxidants and Protease Inhibitors.- II. Immune Complexes and Endothelial Injury.- III. Clastogenic Products.- IV. Lipid Peroxidation Products.- V. Prostanoid Metabolism.- VI. Reactive Oxidants as Modulators of Inflammation.- H. Oxidative Injury in Skin Diseases.- I. Skin Diseases with Vasculitis.- 1. Neutrophilic Vasculitis.- 2. Lymphocytic Vasculitis.- II. Mesenchymal Autoimmune Disorders.- 1. Systemic Lupus Erythematosus.- 2. Progressive Systemic Sclerosis.- III. Skin Diseases with Tissue Neutrophilia.- 1. Psoriasis Vulgaris.- 2. Sweet's Syndrome.- 3. Dermatitis Herpetiformis Duhring.- IV. Skin Diseases with Tissue Eosinophilia.- 1. Bullous Pemphigoid.- 2. Pemphigus Herpetiformis.- V. Skin Diseases with Tissue Lymphocytosis.- 1. Atopic Dermatitis.- VI. Skin Diseases with Deficiency in Nutritional Antioxidants.- 1. Kwashiorkor Dermatitis.- I. Skin Carcinogenesis.- I. Reactive Oxidants in Carcinogenesis.- II. Reactive Oxygen Species in Tumor Promotion.- III. Peroxides as Tumor Promotors.- IV. Phorbol Ester Type Tumor Promotors.- V. Modulation of Pro- and Antioxidant Skin Enzymes by Tumor Promotors.- VI. Antioxidants as Antipromotors and Antiinitiators.- VII. Endogenous Antioxidants in Skin Neoplasms.- 4 Dermatopharmacology.- A. Chemotherapy.- I. Tocopherol.- II. Superoxide Dismutase.- III. Retinoids.- IV. Carotenoids.- V. Anthralin.- VI. Organic Gold Compounds.- VII. Glucocorticosteroids and Nonsteroidal Antiphlogistic Drugs.- VIII. Tetracyclines.- IX. Metronidazole.- X. Colchicine.- XI. Dapsone.- XII. Clofazimine.- XIII. Thalidomide.- XIV. Iodide.- XV. Chloroquine.- XVI. Flavonoids.- XVII. Zinc.- XVIII. Benzoyl Peroxide.- XIX. Tetrachlorodecaoxide.- XX. Dimethylsulfoxide.- XXI. Hyperbaric Oxygen.- B. Photochemotherapy.- I. 8-Methoxypsoralen.- II. Hematoporphyrin.- III. Goeckermann Therapy.- IV. Ingram Therapy.- 5 Dermatotoxicology.- A. Irritant Contact Dermatitis and Skin Necrosis.- I. Lipid Peroxidation Products.- II. Anticancer Agents.- III. Charge Transfer Mechanism.- IV. Chemical Warfare Agents.- B. Allergic Contact Dermatitis.- C. Chemical-Induced Skin Sclerosis.- I. Paraquat-Induced Lung Fibrosis.- II. Skin Sclerosis.- III. Chemical-Induced Scleroderma.- 1. Quartz.- 2. Bleomycin.- 3. Vitamin K1.- 4. Toxic Oil Syndrome.- 5. Biogenic Amines.- 6. Halogenated Aliphatic Hydrocarbons.- D. Chemical Leukoderma.- E. Chemical-Induced Comedogenesis.- Synopsis.- References.

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