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Overview"The late John ""Jack"" Fowler was a busy radiation biology researcher and teacher who wrote 581 papers over the last 65 plus years. He also received nearly every honour the medical physics field can bestow. This book sums up the key concepts relating to optimum fractionation in radiation therapy that interested him throughout his life. Just under 100 pages in length, this book is a quick, informative, and enjoyable read." Full Product DetailsAuthor: Jack Fowler , Alexandru Dasu , Iuliana Toma-DasuPublisher: Medical Physics Publishing Corporation Imprint: Medical Physics Publishing Corporation ISBN: 9781930524736ISBN 10: 1930524730 Pages: 93 Publication Date: 30 January 2015 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents* Optimum Overall Treatment Time in Radiation Oncology* Chapter 1: The Origins of Linear Quadratics*1.1 A 60+ Year Quest to Find How Fractionation Really Works, 1950 – 2014*1.2 The Linear Quadratic Concept and its Relevance to Clinically Sized Doses* in Radiotherapy*1.3 Time to Think**Chapter 2: LQ Modeling*2.1 The Simplest Modeling*2.2 The Seven Steps to Linear Quadratic Heaven: A Brief Summary*2.3 The Details**Chapter 3: Dose and Effectiveness*3.1 Biologically Effective Dose*3.2 Relative Effectiveness (RE)*3.3 Overall Treatment Time and Tolerances*3.3.1 Late Normal Tissue Complications*3.3.2 Acute Mucosal Tolerance**Chapter 4: Normalized Total Dose*4.1 Converting from BED to NTD or EQD*4.2 Gamma Slopes, the Standard of Prescription of Estimates of BED or NTD*4.3 How to Evaluate a New Schedule – a Summary**Chapter 5: A Review of Schedules*5.1 Some of the Best-known Schedules*5.2 Standard Fractionation*5.3 Hyperfractionation*5.4 RTOG 90-03*5.5 Initially Too Hot in Table 5 – 1*5.6 General Considerations*5.7 The Danish Six Fractions a Week*5.8 Appropriateness of LQ Modeling**Chapter 6: How to Obtain Curves with Peaks of Optimum Overall Treatment Times*6.1 Differences Between 7 Days and 3 – 4 Weeks in Tk*6.2 The Problem of Finding an Optimum Overall Time**Chapter 7: Time and Repopulation*7.1 Results vs Days of Overall Time*7.1.1 Two Fractions a Day Give More Tumor Log Cell Kill than One Fraction a Day*7.1.2 The Effect of Assuming Faster or Slower Repopulating Rates*7.2 Discussion: The Exceptional Cases of Very Fast Repopulation**Chapter 8: Should We Ever Use One Fraction a Day?*8.1 Discussion: Is One Fraction a Day Still to Be Used?*8.2 Main Conclusions*8.2.1 Conclusion #1: 2F/Day is Nearly Always Better than 1F/Day*8.2.2 Conclusion #2: Investigate Repopulation Rates for Use in Longer Schedules*8.3 Discussion: Smaller and Smaller Fractions*8.4 Discussion: How Long Is Really Too Long?**Chapter 9: How Short is Too Short?*9.1 Introduction*9.2 Acute Tolerance Calculations Are Also Worth Doing**Chapter 10: Recovery*10.1 Incomplete Recovery*10.2 Incomplete Recovery as a Loss of Effect in Prolonged Fractions**Chapter 11: The Influence of Inter-patient Heterogeneity*11.1 Introduction*11.2 Tumor Control Probability Modeling*11.3 Results and Discussion*11.4 Summary**Chapter 12: Final Thoughts* Photographs* Glossary* References and Additional ResourcesReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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