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OverviewFull Product DetailsAuthor: Jiapu ZhangPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 1st ed. 2023 Volume: 23 Weight: 1.622kg ISBN: 9783031367724ISBN 10: 3031367723 Pages: 953 Publication Date: 17 October 2023 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsIntroduction1 Papain-Like cysteine protease (PLpro) 2 3C-Like protease (3CLpro) 3 RNA-dependent RNA polymerase (RdRp) 4 RNA-helicase 5 RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+] 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA] 7 Spike (S) glycoprotein 8 Spike (S) glycoprotein D614G mutant 9 Spike (S) glycoprotein N501Y mutant 10 Spike (S) glycoprotein N165A-and-N234Amutant 11 SARS (SARS-CoV-1) 12 MERS-coronavirus (MERS) 13 Human-ACE2, human-L6, human-L6R 14 PLpro binding with 12 compounds 15 3CLpro binding with N3/Lopinavir/Ritonavir 16 3CLpro dimer binding with 7 HIV-inhibitors and Others 17 Spike RBDs binding with 50 drugs 18 Human ACE2 ectodomain binding with 78 drugs 19 Spike-and-ACE2 binding with 100 drugs 20 Envelope protein (E-protein) 21 Membrane glycoprotein (M-protein) 22 Nucleocapsid phosphoprotein (N-protein) 23 SARS-CoV-2 RNA genome 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14 25 NSP15 26 Other mutants 26.3.1 The alpha-, beta-, delta-, and kappa-variant 26.3.2 The P.1-variant (i.e. gamma-variant) 26.3.3 The alpha1-, alpha2-, beta-, delta-variant, and the wt 26.3.4 The alpha-, beta-, delta-, epsilon-, kappa-, and omicron-variant optimized 26.3.5 Omicron-variants 27 Vaccines and Drugs 28 Pandemic Mathematical Models, Epidemiology and Virus Origins Appendix Mathematical Optimization Algorithms and Free Energy Calculations References IndexReviewsAuthor InformationDr Jiapu Zhang received bachelor degree in 1993, first master degree in research in 1996, both from Qufu Normal University, P.R. China; second master degree in research in 2000 from National University of Singapore, Republic of Singapore; a PhD degree in 2005 from Federation University, Australia; and then a formal postdoctoral fellowship training from CSIRO (Commonwealth Scientific and Industrial Research Organisation), Australia. Dr Zhang also received honors in Australia and worldwide for his prion research. In 2011, the report of MIT (Massachusetts Institute of Technology) Technology Review on his prion results caused worldwide impacts so that several organizations (e.g., the Physics Society of Iran) published his prion results in seven languages. NHMRC (National Health and Medical Research Council) of Australia has assigned him review tasks on prion projects. CSIRO once conferred him an award (together with Drs. Varghese JN and Epa VC) for rabbit prion protein research. He has been a reviewer for many top academic journals (e.g., Nature). All these made Dr. Zhang feel honored for his prion research. Tab Content 6Author Website:Countries AvailableAll regions |
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