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OverviewThe study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student Full Product DetailsAuthor: Moshe Vaniv , Jacques GhysdaelPublisher: Birkhauser Verlag AG Imprint: Birkhauser Verlag AG ISBN: 9783764354862ISBN 10: 3764354860 Pages: 248 Publication Date: June 1997 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Out of Stock Indefinitely Availability: Out of stock  Table of ContentsOncogenes encoding transcription factors, J. Ghysdael and M. Yaniv; Myc structure and formation, G.C. Prendergast; the ETS family of transcriptional regulators, J. Ghysdael and A. Boureux; myb proto-oncogene product as a transcriptional regulator, S Ishii; the v-erbA oncogene, A. Rascle, O Gandrillon, G. Cabello, and J. Samarut; rel proteins and their inhibitors: a balancing act, M.L. Mackichan and A. Israel; structure/function and oncogenic conversion of Fos and Jun, A.J. Bannister and T. Kouzarides.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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