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OverviewNucleic Acids presents an up-to-date and comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function. With a targeted audience of 1) molecular biologists, 2) physical biochemists, and 3) physical chemists, the book has been carefully organized to reach three different audiences while requiring only introductory physical chemistry and molecular biology as prerequisites. Nucleic Acids will serve as a textbook in physical biochemistry and biophysical chemistry classes, as well as a supplemental text in courses on nucleic acid biochemistry or molecular biology, and as a personal reference for students and researchers in these fields. Key Features Organized according to a systematic consideration of techniques used in the study of nucleic acid structure and properties. Key topics – such as protein-DNA and protein-drug complexes, conformational transitions, characterization of nucleic acids by gel and solution techniques, and behavior of supercoiled DNA – are covered in great detail as veritable mini-monographs. Heavily illustrated with diagrams, graphs, and molecular structures, including nearly 2 dozen color figures. Includes numerous figures, tables and an extensive bibliography to facilitate use as a reference volume. Full Product DetailsAuthor: Victor A. Bloomfield , Donald M. Crothers , Ignacio TinocoPublisher: University Science Books,U.S. Imprint: University Science Books,U.S. Dimensions: Width: 18.30cm , Height: 4.30cm , Length: 25.90cm Weight: 1.580kg ISBN: 9780935702491ISBN 10: 0935702490 Pages: 794 Publication Date: 17 April 2000 Audience: College/higher education , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1. Introduction 2. Bases, Nucleosides and Nucleotides 3. Chemical and Enzymatic Methods 4. Nucleic Acid Structures from Diffraction Methods 5. Structure and Dynamics by NMR 6. Electronic and Vibrational Spectroscopy 7. Theoretical Methods 8. Conformational Changes 9. Size and Shape of Nucleic Acids in Solution 10. Supercoiled DNA 11. Interaction of Nucleic Acids with Water and Ions 12. Interaction and Reaction with Drugs 13. Protein-Nucleic Acid Interactions 14. Higher Order Structure IndexReviews"""It was a pleasure to review this book, which is a suitable textbook for graduate courses in physical biochemistry. It provides an update for the widely used text by Cantor and Schimmel...I would recommend this text for graduate classes in physical biochemistry.""--Journal of the American Chemical Society (2000, 122 (46), pg. 11570) ""Overall, this is an excellent book that should find use in graduate level biophysical chemistry and physical biochemistry courses and as a reference for physical chemists, physical biochemists, and molecular biologists.""--Journal of Medicinal Chemistry (2000, Vol. 43, No. 24, pg. 4721) ""This work effectively closes a gap in the scientific literature where a comprehensive, updated book has been long overdue. Written by three recognized worldwide experts in the field, the book acts as an up-to-date encyclopedia of nucleic acids with an emphasis on implications for biological functions.""--Drug Discovery Today" It was a pleasure to review this book, which is a suitable textbook for graduate courses in physical biochemistry. It provides an update for the widely used text by Cantor and Schimmel...I would recommend this text for graduate classes in physical biochemistry. --Journal of the American Chemical Society (2000, 122 (46), pg. 11570) Overall, this is an excellent book that should find use in graduate level biophysical chemistry and physical biochemistry courses and as a reference for physical chemists, physical biochemists, and molecular biologists. --Journal of Medicinal Chemistry (2000, Vol. 43, No. 24, pg. 4721) This work effectively closes a gap in the scientific literature where a comprehensive, updated book has been long overdue. Written by three recognized worldwide experts in the field, the book acts as an up-to-date encyclopedia of nucleic acids with an emphasis on implications for biological functions. --Drug Discovery Today Author InformationVICTOR A. BLOOMFIELD, University of Minnesota DONALD M. CROTHERS, Yale University IGNACIO TINOCO, University of California, Berkeley Tab Content 6Author Website:Countries AvailableAll regions |
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