Overview

This is one of the first books that focuses on emerging concepts about the role of the structure of chromatin, the organization of the genome, and the structure of the interphase nucleus in the control of gene expression in eukaryotes. The first section analyses the relationship between the dynamic chromatin structure at the nucleosome level and gene expression. Section two looks into higher order chromatin structure in relation to transcription. In section three the molecular basis of epigenetic phenomena, like X-chromosome inactivation is discussed, starting from our understanding of chromatin structure. Together, these topics form the molecular basis for our understanding of cell differentiation, knowledge that is essential for the design of transgenic animals and plants and for gene therapy in humans. The book is of direct interest to students that are new in the field and to investigators in the area of biomolecular sciences, like developmental biology, biochemistry, cell biology, microbiology and genetics. Also, those working in applied fields of research, i.e biotechnology and biomedicine, will strongly benefit from this book. It will help them to understand fundamental problems in transgenics and gene therapy. Importantly, a variety of human disorders may turn out to be caused by genetic or somatic errors related to this level of gene control.

Full Product Details

Author:   Roel Van Driel (E.C. Slater Institute, University of Amsterdam) ,  Arie P. Otte (E.C. Slater Institute, University of Amsterdam)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 16.20cm , Height: 2.10cm , Length: 24.10cm
Weight:   0.649kg
ISBN:  

9780198549239

ISBN 10:   0198549237
Pages:   308
Publication Date:   16 October 1997
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Introduction, general perspective, scope of book, key questions Part 1: Nucleosome Dynamics and Transcription 1.2: Role of a positioned nucleosome in constitutive repression and hormone induction of the MMTV promoter 1.3: Histone modification and transcriptional competence 1.4: Mechanisms for alleviating chromatin-mediated repression of transcription Part 2: Higher Order Structure of the Genome and the Nucleus 2.1: Chromatin domains and boundary elements 2.2: Nuclear matrix associated regions 2.3: The chicken lysozyme chromatin domain 2.4: Locus control regions 2.5: Interphase chromosome positions and structure during silencing, transcription and replication 2.6: Genes and transcripts in the interphase nucleus Part 3: Biological Structure and Epigenetic Control of Gene Expression 3.1: DNA methylation and genomic imprinting 3.2: X chromosome inactivation and heritable chromatin structure 3.3: Drosophila heterochromatin: retreats for repeats 3.4: Mechanisms of heritable gene silencing during development of Drosophila 3.5: Heterochromatin and regulation of gene expression in Saccharomyces cerevisiae 3.6: Homology-dependent gene silencing in transgenic plants and related phenomena in other eukaryotes

Reviews

<br> [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology<p><br>

[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology

[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology T his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . T he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology

[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology<br>

<br> [T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field. --The Quarterly Review of Biology<br>

Author Information

Dr Roel Van Driel, E.C Slater Institut, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands. Tel: +31 20 525 5150; Fax:+31 20 525 5124: Email: van.driel@chem.uva.nl Dr Arie P Otte, E. C Slater Institut, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands. Tel: +31 20 525 5150; Fax:+31 20 525 5124; Email: a311arie@horus.sara.nl

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