Overview

Extending the use of nitroxides as probes into more complex systems such as viable cells and whole animals requires greater knowledge of their interactions in functioning biological systems and appropriate model systems. Nitroxide Spin Labels: Reactions in Biology and Chemistry presents information essential for research in this area. Nitroxide research offers the promise of important new ways of measuring metabolism and will be useful in the diagnosis of important disease categories such as cancer, inflammation, and ischemia.

Full Product Details

Author:   Marjeta Sentjurc ,  Nickolai Kocherginsky (Inst of Chemical Physics, Moscow, Russia) ,  Harold M. Swartz
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 2.00cm , Length: 23.40cm
Weight:   0.598kg
ISBN:  

9780849342042

ISBN 10:   084934204
Pages:   288
Publication Date:   11 May 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Introduction General Considerations Use of Nitroxides as Contrast Agents for Nuclear Magnetic Resonance Imaging and Spectroscopy EPR Imaging and In Vivo EPR Techniques Measurements of the Concentration of Oxygen Measurement of Diffusion Measurement of Viability Measurement of Temperature Summary and Plan of the Book Terminology, Classification, and Distribution of the Nitroxides in Cells General Analysis and Terminology Classification Distribution of Nitroxides in Cells General Considerations Distributions of Neutral Nitroxides Location of Charged Nitroxides in Cells Location of Doxyl Strearates and Related Lipophilic Nitroxides Location of Phospholipids Labeled with Nitroxides Chemical Reactivity of Nitroxides General Aspects Stability of Pure Solutions Electrochemical Reactions Reduction Mechanisms of Chemical Reduction Reduction of f-Phenylenediamine Reduction by Metal Ions Reduction of Nitroxides by Ascorbic Acid and Flavins Reoxidation of Hydroxylamines and Amines to Nitroxides Interconversion of Hydroxylamines and Nitroxides Reduction of Nitroxides by SH-Containing Substances Reactions of Free Radicals with Nitroxides Photochemical Reactions Nitroxides as Redox Probes of Melanin Interactions with Singlet Oxygen Radiation-Induced Reactions Reduction Reactions Oxidation Reactions Radiosensitization by Nitroxides Inhibition of Lipid Peroxidation Reactions of Superoxide with Nitroxides Nitroxides as Catalysts of Radical Reactions Spin Trapping Challenges for Chemists and Biochemists Applications of Reactions of Nitroxides in Biophysics General Considerations The Kinetics and Mechanism of Reduction of Nitroxides by Ascorbic Acid Investigations of Model and Biological Membranes Transport of Ascorbate The Kinetics of Reductions in Membranes Reduction of Spin-Labeled Lipids Dynamics of Lipids Membrane Permeability an

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Kocherginsky\, Nickolai; Swartz\, Harold M.

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