Overview

As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.

Full Product Details

Author:   Breehn R Landseer
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   1.050kg
ISBN:  

9781600213854

ISBN 10:   1600213855
Pages:   393
Publication Date:   02 August 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface; Molecular Targeting of DNA Repair: A Means to Improve Therapeutic Index; DNA Repair and Lung Cancer; Comet Assay as a Tool to Evaluate DNA Repair Activity and Inhibition; Dietary Compounds that Enhance DNA Repair and their Relevance to Cancer and Ageing; Gene Prophylaxis of Endogenous DNA Damage; Translesion DNA Synthesis-A Fundamental DNA Damage Tolerance Mechanism; Long Term RNA Interference: Toward a Set of Isogeneic Human Deficient Cells in DNA Repair Genes; Peculiarities of Base Excision Repair in Loach Embryogenesis; Roles of Plant Transcription Factor IIH Subunit Homologs in Nucleotide Excision Repair and Transcription; Repair of Radiation-induced DNA Double-strand Breaks in Human Cells: History, Progress and Controversies; DNA Double-strand Breaks Repair Pathways in the Framework of Chromatin Index; Role of p53 in the Repair of Ionising Radiation-Induced DNA Damage; Index.

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