Overview

Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term “regenerative medicine” was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general. Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cellcycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerative disease, are recurring themes throughout the book. We are all now part of the regeneration revolution.

Full Product Details

Author:   Ellen Heber-Katz ,  David L. Stocum
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2013 ed.
Volume:   367
Dimensions:   Width: 15.50cm , Height: 4.30cm , Length: 23.50cm
Weight:   0.606kg
ISBN:  

9783642358098

ISBN 10:   3642358098
Pages:   281
Publication Date:   11 April 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis.- Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals.- Cellular Plasticity During Vertebrate Appendage Regeneration.- Cell Signaling Pathways in Vertebrate Lens Regeneration.- Regenerative Medicine: Challenges and Perspectives for Successful Therapies.- Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects.- Muscle Repair and Regeneration:  Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration.- Neural Regeneration.- Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System.- Epigenetics and Regeneration.- Cell Cycle Regulation and Regeneration.      ​

Reviews

This is an outstanding textbook about limb bud regeneration into fully functional limbs in fish, mammals, and amphibian species. The operative signaling including full color microscopic images and diagrams is provided. I highly commend it for all devoted scientists. (Joseph J. Grenier, Amazon.com, September, 2015)

“This is an outstanding textbook about limb bud regeneration into fully functional limbs in fish, mammals, and amphibian species. … The operative signaling including full color microscopic images and diagrams is provided. I highly commend it for all devoted scientists.” (Joseph J. Grenier, Amazon.com, September, 2015) 

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions