Overview

This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms or organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.

Full Product Details

Author:   Hirokawa
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   No. 16
Weight:   0.822kg
ISBN:  

9780849377419

ISBN 10:   0849377412
Pages:   300
Publication Date:   12 January 1994
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Overview: The Neuronal Cytoskeleton: Roles in Neuronal Morphogenesis and Organelle Transport, N. Hirokawa Molecular Genetics of Kinesin Motors, L.S.B. Goldstein Characterization of Human Kinesin Heavy Chain Genes, R. Vale, F. Navone, J. Niclas, and N. Hom-Booher The Molecular Basis of Fast Axonal Transport, G.S. Bloom Regulation of Organella Transport by Phosphorylation of Kinesin and by Decoration of Microtubules with Microtubule-Associated Proteins, R. Sato-Yoshitake, Y. Okada, S. Okabe, T. Umeyama, and N. Hirokawa Axonal Homeostasis and the Nature of Regulated Retrograde Organelle Transport, P.J. Hollenbeck and R.S. Weld Kinectin: A Kinesin Receptor on Endoplasmic Reticulum, I. Toyoshima and M.P. Sheetz Neurogenesis and Cytoskeleton: Expression of the Nestin Intermediate Filament in Neurepithelial Stem Cells, L.B. Zimmerman and R.D.G. McKay Molecular and Developmental Studies of Neuronal Intermediate Filaments, G.Y. Ching, M.P. Kaplan, and R.K.H. Liem Gelsolin is Involved in Myelin Formation, J. Tanaka and K. Sobue Dynamics of the Neuronal Cytoskeleton, S. Okabe and N. Hirokawa Sites of Microtubule Assembly in Growing, M.M. Black and A. Brown Regulation of Tubulin Organization in the Axon, T. Tashiro Steroid Hormone Effect of Neuronal Configuration-In Vivo and In Vitro Studies, M. Kawata, K. Yuri, N. Morita, and M. Morimoto Microtubule Bundling by Tau Proteins In Vivo, Y. Kanai and N. Hirokawa Nuclear Tau Proteins: Implications in Alzheimer's Disease and Down Syndrome, R.P. Zinkowski, R.E. Powers, P.A. Loomis, Y. Wang, and L.I. Binder Tau Proteins and Alzheimer's Disease, M. Goedert Abnormal Phosphorylation of Tau in the Alzheimer's Disease Brain, M. Hasegawa, M. Morishima, K. Takio, M. Suzuki, A. Watanabe, T. Arai, K. Titani, and Y. Ihara Ca2+-Dependent Regulation of the Neuronal Cytoskeleton, K. Sobue Annexin VI-Binding Proteins in Brain, M. Inui, T. Watanabe, M. Iga, B.-Y. Chen, and K. Sobue Is Dynamin GTPase a Microtubule Associated Motor?, T. Nakata, Y. Noda, K. Maeda, R. Sato-Yoshitake, Y. Okada, R. Takemura, and N. Hirokawa Compartmentation of p60c-src Complex in Developing Rat Forebrain Membrane, K. Ozawa, S. Tadokoro, M. Kira, M. Takahashi, O. Takeuchi, and K. Sobue Identifying Novel Synapse Associated Proteins, C.C. Garner, A. Garner, B. Vob, U. Appeltauer, and E.D. Gundelfinger) Subject Index Author Index

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions