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OverviewNeurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management. In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological, and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand. Full Product DetailsAuthor: Michael G. HannaPublisher: Elsevier - Health Sciences Division Imprint: Elsevier - Health Sciences Division ISBN: 9780323908207ISBN 10: 0323908209 Pages: 292 Publication Date: 27 September 2024 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of Contents1. Introduction and pathophysiological themes across the neurologic channelopathies 2. Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies 3. Inherited Myotonias 4. Periodic Paralysis? 5. Andersen-Tawil syndrome 6. Congenital myasthenic syndromes 7. Human pain channelopathies 8. The Episodic Ataxias 9. Familial Hemiplegic Migraine 10. Paroxysmal Movement Disorders 11. Epilepsies 12. Myasthenia Gravis 13. Neuromyotonia 14. Stiff person Syndrome 15. Autoantibody-mediated central nervous system channelopathies 16. Pediatric Neuromuscular ChannelopathiesReviewsAuthor InformationMichael G Hanna is Director of the UCL Institute of Neurology, University College London and professor in clinical neurology and consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, and also Director of the Medical Research Council (MRC) Centre for Neuromuscular Disease. He has published over 100 peer-reviewed papers in neurology, authored 15 book chapters and one book in clinical neurology. He serves as editor of the journal of Neurology, Neurosurgery, and Psychiatry.and is co-author of the textbook Tutorials in Differential Diagnosis, 4e. Tab Content 6Author Website:Countries AvailableAll regions |
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