Overview

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Full Product Details

Author:   Dennis S. Charney (Chief, Mood and Anxiety Disorders Research Program, Chief, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, USA) ,  Eric J. Nestler ,  Pamela Sklar ,  Joseph D. Buxbaum
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Edition:   4th Revised edition
Dimensions:   Width: 21.60cm , Height: 4.70cm , Length: 27.80cm
Weight:   2.844kg
ISBN:  

9780199398461

ISBN 10:   0199398461
Pages:   1248
Publication Date:   19 June 2014
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
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Table of Contents

Table of Contents ; Contributors ; Preface ; SECTION 1: Introduction to Basic Neuroscience ; Eric J. Nestler ; 1. Overview of Brain Development ; John L. R. Rubenstein ; 2. Neurochemical Systems in the Central Nervous System ; Ariel Y. Deutch and Robert H. Roth ; 3. Principles of Electrophysiology ; Evelyn K. Lambe ; 4. Principles of Signal Transduction ; Jean-Antoine Girault and Paul Greengard ; 5. Synaptic and Neural Plasticity ; Said Kourrich and Antonello Bonci ; 6. Principles of Molecular Biology ; Steven E. Hyman and Eric J. Nestler ; 7. Epigenetics of Psychiatric Diseases ; Bryan E. McGill and Huda Y. Zoghbi ; SECTION 2: Emerging Technologies ; Karl Deisseroth ; 8. Transgenic Tools and Animal Models of Mental Illness ; Lisa M. Monteggia, William Carlezon, Jr. and Ralph J. DiLeone ; 9. Application of Stem Cells to Understanding Psychiatric Disorders ; Kimberly M. Christian, Hongjun Song and Guo-li Ming ; 10. Optogenetic Technologies for Psychiatric Disease Research: Current Status and Challenges ; Lief E. Fenno and Karl Deisseroth ; 11. Applications of Focused Ultrasound ; Elisa E. Konofagou ; 12. Genetic Methodologies and Applications ; Shaun M. Purcell ; 13. The Brain and Its Epigenome ; Amanda C. Mitchell, Yan Jiang, Cyril J. Peter, Ki A. Goosens and Schahram Akbarian ; 14. Network Methods for Elucidating the Complexity of Common Human Diseases ; Eric E. Schadt ; 15. Brain Imaging Methodologies ; Hanzhang Lu, Yihong Yang and Peiying Liu ; 16. Image-Guided Brain Stimulation ; Mark S. George, John J. Taylor and Jaimie Henderson ; SECTION 3: Psychotic Disorders ; Pamela Sklar ; 17. Diagnosis of the Psychoses ; Lianne Morris Smith, Julie W. Messinger and Dolores Malaspina ; 18. Genetics of Schizophrenia and Bipolar Disorder ; Pamela Sklar ; 19. Genomic Syndromes in Schizophrenia: Overlapping Phenotypes ; George Kirov, Michael O'Donovan and Michael J. Owen ; 20. Neuroimaging of Psychotic Disorders ; Stephan Heckers, Neil Woodward and Dost Ongur ; 21. Cognitive and Motivational Neuroscience of Psychotic Disorders ; Alan Anticevic, Erin C. Dowd and Deanna M. Barch ; 22. Mouse Models of Schizophrenia and Bipolar Disorder ; Mikhail V. Pletnikov and Christopher A. Ross ; 23. Cortical GABA Neurons in Schizophrenia ; Allison A. Curley and David A. Lewis ; 24. Synaptic Disease in Psychiatry ; Seth G. N. Grant ; 25. Neurodevelopment and Schizophrenia ; Ester J. Kwon, Takahiro Soda and Li-Huei Tsai ; 26. Psychosis Proneness ; Raquel E. Gur ; 27. Neurochemistry and Pharmacotherapy ; Carol A. Tamminga and Elena I. Ivleva ; 28. Neurobiology of Bipolar Disorder ; Kate Burdick, Stephen Haggarty and Roy Perlis ; SECTION 4: Mood Disorders ; Helen S. Mayberg ; 29. The Diagnosis of Mood Disorders ; Jan Fawcett and Brant Hager ; 30. Genetics of Depression ; Douglas F. Levinson ; 31. Animal Models of Mood Disorders ; Georgia E. Hodes and Scott J. Russo ; 32. Molecular and Cellular Pathogenesis of Depression and Mechanisms for Treatment Response ; Ronald S. Duman ; 33. Pathogenesis of Depression: Clinical Studies ; Maura A. Furey, Daniel C. Mathews and Carlos A. Zarate Jr. ; 34. Neural Circuitry of Depression ; Joseph L. Price and Wayne C. Drevets ; 35. Neurobiology of Depression in Later Life: Anatomy of Melancholia ; K. Ranga Rama Krishnan ; 36. Gonadal Steroids and Mood Disorders ; David R. Rubinow, Peter J. Schmidt and Claire D. Craft ; 37. Depression and Medical Illness ; Tami D. Benton, Joshua Blume, Paul Crits-Christoph, Benoit Dube and Dwight L. Evans ; 38. Treatments for Depression ; Dan V. Iosifescu, James W. Murrough and Dennis S. Charney ; SECTION 5: Anxiety Disorders ; Kerry J. Ressler ; 39. Diagnosis of Anxiety Disorders ; Meghan E. Keough, Murray B. Stein and Peter P. Roy-Byrne ; 40. Genetics of Anxiety Disorders ; Javier A. Perez, Takeshi Otowa, Roxann Roberson-Nay and John M. Hettema ; 41. The Neurobiology of Fear and Anxiety: Contributions of Animal Models to Current Understanding ; Christopher K. Cain, Gregory Sullivan and Joseph E. LeDoux ; 42. Differential roles of GABA Receptors in Anxiety ; Hanns Mohler ; 43. Prefrontal Cortex Regulation of Emotion and Anxiety ; Bronwyn M. Graham and Mohammed R. Milad ; 44. Developmental Components of Fear and Anxiety in Animal Models ; Siobhan S. Pattwell, Anne-Marie Mouly, Regina M. Sullivan and Francis S. Lee ; 45. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders ; Madeleine S. Goodkind, Anett Gyurak and Amit Etkin ; 46. Novel Treatment Approaches for Anxiety Disorders ; Anita Van Zwieten, Gail A. Alvares & Adam J. Guastella ; 47. Pharmacotherapy of Anxiety Disorders ; Dan V. Iosifescu, James W. Murrough and Dennis S. Charney ; 48. Neurobiology and Treatment of OCD ; Susanne E. Ahmari and H. Blair Simpson ; 49. Neurobiology and Treatment of PTSD ; Karen E. Murray, Orion P. Keifer, Jr., Kerry J. Ressler, Seth Davin Norrholm and Tanja Jovanovic ; SECTION 6: Substance Use Disorders ; Antonello Bonci and Nora Volkow ; 50. Animal Models of Addiction ; Christopher J. Evans, Rafael Maldonado Lopez and Yvette F. Tache ; 51. Cellular and Molecular Mechanisms of Addiction ; Kathryn J. Reissner and Peter W. Kalivas ; 52. The Genetic Basis of Addictive Disorders ; David Goldman ; 53. Brain Development and the Risk for Substance Abuse ; Kristina Caudle and BJ Casey ; 54. Molecular Imaging in Addictive Disorders ; Chelsea L. Robertson, Steven M. Berman and Edythe D. London ; 55. Brain, Reward, and Drug Addiction ; Vani Pariyadath, Martin P. Paulus and Elliot A. Stein ; 56. Magnetic Resonance Spectroscopy Studies in Substance Abusers ; Linda Chang, Christine C. Cloak and John L. Holt ; 57. Pharmacotherapy of Substance Use Disorders ; Jane B. Acri and Philip Skolnick ; 58. Epidemiology of Substance Use Disorders ; Denise B. Kandel, Mei-Chen Hu and Pamela C. Griesler ; SECTION 7: Dementia ; David M. Holtzman ; 59. Clinical and Neuropsychological Features of Alzheimer's Disease ; Jason Hassenstab, Jeffrey Burns and John C. Morris ; 60. The Genetics of Alzheimer's Disease ; Rudolph E. Tanzi ; 61. Experimental Animal Models of Alzheimer's Disease ; Dave Morgan ; 62. Structural, Functional and Molecular Neuroimaging Biomarkers for Alzheimer's Disease ; James B. Brewer, Jorge Sepulcre and Keith A. Johnson ; 63. Fluid Biomarkers for Alzheimer's Disease ; Anne M. Fagan ; 64. Current Therapies for Alzheimer's Disease ; Mary Sano and Judith A. Neugroschl ; 65. Disease-Modifying Therapies for Alzheimer's Disease ; Joshua D. Grill and Jeffrey Cummings\ ; 66. Lewy Body Dementias ; Stella Karantzoulis and James E. Galvin ; 67. Clinical Features and Pathogenesis of FTD ; Georges Naasan and Bruce Miller ; 68. Pathogenesis, Diagnosis and Treatment of Vascular and Mixed Dementias ; Helena Chang Chui ; 69. Clinical Features and Pathogenesis of Prion Disease ; Joel Watts and Michael D. Geschwind ; SECTION 8: Psychiatric Disorders of Childhood Onset ; Joseph D. Buxbaum ; 70. Epidemiology of Neuropsychiatric and Developmental Disorders of Childhood ; Elise Robinson, Benjamin Neale and Mark J. Daly ; 71. Rare Variants of Substantial Effect in Psychiatric Disorders of Childhood Onset ; Heather C. Mefford ; 72. Epigenetics in Early Life Programming ; Tracy L. Bale ; 73. Animal Models in Psychiatric Disorders of Childhood Onset ; Richard Paylor, Alexia M. Thomas, Surabi Veeraragavan and Shannon M. Hamilton ; 74. Neuropathology and Synaptic Alterations in Neurodevelopmental Disorders ; Mara Dierssen and Salvador Martinez ; 75. Functional Connectivity: Application to Developmental Disorders ; Luke Bloy, Ragini Verma and Timothy P.L. Roberts ; 76. Intellectual Disability Syndromes ; Charles E. Schwartz, Fiorella Gurrieri and Giovanni Neri ; 77. Autism Spectrum Disorders ; Alexander Kolevzon, A. Ting Wang, David Grodberg and Joseph D. Buxbaum ; 78. Neurobiology of Attention Deficit Hyperactivity Disorder ; Stephen V. Faraone and Joseph Biederman ; 79. Tourette Syndrome and Tic Disorders ; Kyle Williams, Michael H. Bloch, Matthew W. State and Christopher Pittenger ; 80. Novel Therapeutics in Childhood Onset Psychiatric Disorders ; Dorothy E. Grice, Alexander Kolevzon, Walter E. Kaufmann and Joseph D. Buxbaum ; SECTION 9: Special Topic Areas ; Dennis S. Charney ; 81. DSM-5 Overview and Goals ; David J. Kupfer and Susan K. Schultz ; 82. The Infirmities of Psychiatric Diagnosis ; Steven E. Hyman ; 83. Toward Precision Medicine in Psychiatry: The NIMH Research Domain Criteria Project ; Bruce N. Cuthbert and Thomas R. Insel ; 84. Neurobiology of Personality Disorders: The Shift in DSM-5 ; M. Mercedes Perez-Rodriguez, Antonia S. New and Larry J. Siever ; 85. The Neurobiology of Aggression ; R. James R. Blair ; 86. Neurobiology of Social Attachment ; Adam S. Smith, Kelly Lei and Zuoxin Wang ; 87. The Neurobiology of Sleep ; Giulio Tononi and Chiara Cirelli ; 88. The Neurobiology of Resilience ; Adriana Feder, Margaret Haglund, Gang Wu, Steven M. Southwick and Dennis S. Charney ; 89. Neurobiology of Eating Disorders ; Thomas B. Hildebrandt ; Index

Reviews

The fourth edition of Neurobiology of Mental Illness represents a remarkable contribution to promote the integration of psychiatry into biomedical sciences... [It] will be a very useful text to be adopted for trainees in psychiatry and students interested in the field of neuroscience but also for all those interested who need to keep up to date with their knowledge in the field. Antonio Ventriglio, ASUR; University of Foggia, Italy; International Journal of Social Psychiatry, 2015, Vol. 62 (1)

Author Information

Dennis S. Charney, MD is Dean at the Icahn School of Medicine at Mount Sinai, Executive Vice President for Academic Affairs, The Mount Sinai Medical Center, and Anne and Joel Ehrenkranz Professor in the Departments of Psychiatry, Neuroscience, and Pharmacology & Systems Therapeutics at the Icahn School of Medicine at Mount Sinai in New York, NY. He is a world expert in the neurobiology and treatment of mood and anxiety disorders. He has made fundamental contributions to the understanding of neural circuits and neurochemistry related to human anxiety, fear, mood and discovery of new treatment for mood and anxiety disorders. He later expanded this area into pioneering research related to the psychobiological mechanisms of human resilience to stress. His work has been carried out over two decades at Yale University School of Medicine, and during four years at the National Institute of Mental Health (NIMH). It continues today at the Icahn School of Medicine at Mount Sinai.

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