Overview

This text is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of the nervous system. It covers the neurobiology of actin ranging from basic cellular organization and function to the roles of actin in the health and disease states of the nervous system. Its opening chapter presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in a cellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The latter section of the book then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested in investigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters.

Full Product Details

Author:   Gianluca Gallo ,  Lorene M Lanier
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2011 ed.
Volume:   5
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.450kg
ISBN:  

9781461427254

ISBN 10:   1461427258
Pages:   282
Publication Date:   25 December 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction to the Neurobiology of Actin.- The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia.- Regulation of Actin Filaments During Neurite Extension and Guidance.- Functions of Myosin Motor Proteins in the Nervous System.- Microtubule-Actin Interactions During Neuronal Development.- Working with Actin: Methodological Approaches for the Study of Actin in Neurons.- Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous System.- Actin Cytoskeletal Regulation in Neuronal Migration.- Actin and Neuronal Polarity.- Actin at the Synapse: Contribution to Pre and Post-synaptic Functions.- Actin and Diseases of the Nervous System.- Signal Transduction Pathways: From Receptor to the Actin Cytoskeleton.

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