Overview

To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

Full Product Details

Author:   Eric Vivier ,  James Di Santo ,  Alessandro Moretta
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   395
Weight:   0.454kg
ISBN:  

9783319795546

ISBN 10:   3319795546
Pages:   247
Publication Date:   14 March 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Transcriptional control of NK cells.- Development, Homeostasis and Heterogeneity of NK cells and ILC1.- Diversification and functional specialization of human NK cell subsets.- Dynamic regulation of NK cell responsiveness.- Sweet is the memory of past troubles: NK cells remember.- Lessons from NK cell deficiencies in the mouse.- Probing human NK cell biology using Human Immune System (HIS) mice.- Haploidentical-Haematopoietic Stem Cell Transplantation: role of NK cells and effect of cytomegalovirus infections.- The past, present and future of NK cells in hematopoietic cell transplantation and adoptive transfer.- NK cells and Cancer Immunoediting.

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Author Information

Prof. Eric Vivier, Centre d'Immunologie de Marseille-Luminy, Marseille, France Prof. James Di Santo, Innate Immunity Unit, Institut Pasteur, Paris, France Prof. Alessandro Moretta, Experimental Medicine at Genoa University, Genoa, Italy

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