Overview

Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications. After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites as smart scaffolds investigated, as is cartilage and bone tissue engineering, regeneration and replacement. With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field.

Full Product Details

Author:   Thomas J. Webster
Publisher:   Elsevier Science & Technology
Imprint:   Woodhead Publishing Ltd
Volume:   49
Dimensions:   Width: 15.60cm , Height: 3.80cm , Length: 23.40cm
Weight:   1.180kg
ISBN:  

9780857092335

ISBN 10:   0857092332
Pages:   704
Publication Date:   19 October 2012
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Replaced By:   9780128186275
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Contributor contact details Woodhead Publishing Series in Biomaterials Dedication Part I: Materials, properties and considerations Chapter 1: Introduction to nanomedicine Abstract: 1.1 Introduction: basic concepts of nanomedicine 1.2 Public perception of nanomedicine 1.3 Scientific principles and applications of nanomedicine 1.4 Future trends in nanomedicine Chapter 2: Trends in nanomedicine Abstract: 2.1 Introduction 2.2 The rise of nanomedicine 2.3 Diagnostics and medical records 2.4 Treatment 2.5 Future trends Chapter 3: Biomedical nanocrystalline metals and alloys: structure, properties and applications Abstract: 3.1 Introduction 3.2 Synthesis and structure of nanocrystalline metals and alloys 3.3 Properties of nanocrystalline metals and alloys 3.4 Biocompatibility of nanocrystalline metals and alloys 3.5 Applications of nanocrystalline metals and alloys 3.6 Future trends 3.7 Sources of further information and advice Chapter 4: Nanoporous gold for biomedical applications: structure, properties and applications Abstract: 4.1 Introduction 4.2 Medical applications 4.3 Biosensor applications 4.4 Alloy formation 4.5 Dealloying of gold–silver alloy 4.6 Mechanical properties of nanoporous gold 4.7 Electronic properties of nanoporous gold 4.8 Conclusions Chapter 5: Hydroxyapatite (HA) coatings for biomaterials Abstract: 5.1 Introduction 5.2 Hydroxyapatite (HA) coatings 5.3 HA coatings by plasma spraying 5.4 Properties of plasma-sprayed coatings 5.5 Biomimetic HA coatings 5.6 HA coatings by sol-gel deposition 5.7 Miscellaneous deposition techniques for HA coatings 5.8 Conclusions 5.9 Future trends 5.10 Acknowledgement Part II: Nanomedicine for therapeutics and imaging Chapter 6: Calcium phosphate-coated magnetic nanoparticles for treating bone diseases Abstract: 6.1 Introduction 6.2 Iron oxide magnetic nanoparticle synthesis 6.3 Surface modification of iron oxide magnetic nanoparticles 6.4 Characterization of iron oxide magnetic nanoparticles 6.5 Biological applications of magnetic nanoparticles 6.6 Conclusions 6.7 Future trends Chapter 7: Orthopedic carbon nanotube biosensors for controlled drug delivery Abstract: 7.1 Introduction 7.2 Carbon nanotubes for electrochemical biosensing 7.3 Carbon nanotube-based in situ orthopedic implant sensors 7.4 Electrically controlled drug-delivery systems for infection and inflammation 7.5 Critical issues in developing in situ orthopedic implantable sensors and devices 7.6 Conclusions Chapter 8: Nanostructured selenium anti-cancer coatings for orthopedic applications Abstract: 8.1 Introduction 8.2 Selenium as an anti-cancer implant material 8.3 Nanostructured selenium coatings: a novel approach of using selenium to create anti-cancer biomaterials 8.4 In vitro biological assays for uncoated and selenium-coated metallic substrates 8.5 The effectiveness of titanium and stainless steel substrates 8.6 Coarse-grained Monte Carlo computer simulation of fibronectin adsorption on nanometer rough surfaces 8.7 Conclusions Chapter 9: Nanoparticulate targeted drug delivery using peptides and proteins Abstract: 9.1 Introduction 9.2 Peptides and proteins for targeted drug delivery 9.3 Drug-peptide conjugates 9.4 Peptide-functionalized drug delivery systems 9.5 Peptide-targeted drug delivery across the intestine 9.6 Peptide-targeted drug delivery across the blood-brain barrier (BBB) 9.7 Peptide-targeted drug delivery for cancer applications 9.8 Peptide-targeted drug delivery for the liver 9.9 Conclusions and future trends Chapter 10: Nanotechnology for DNA and RNA delivery Abstract: 10.1 Introduction to DNA and RNA delivery 10.2 Advanced DNA/RNA delivery approaches in nanotechnology 10.3 Nanomaterial applications for DNA/RNA delivery 10.4 Novel vaccines 10.5 Molecular probes and images 10.6 Conclusions and future trends Chapter 11: Gold nanoshells for imaging and photothermal ablation of cancer Abstract: 11.1 Introduction 11.2 The impact of cancer 11.3 Cancer biology 11.4 Nanotechnology and cancer treatment 11.5 Nanoshells 11.6 Conclusions and future trends 11.7 Sources of further information and advice 11.8 Acknowledgments Chapter 12: Microfluidics for testing and delivering nanomedicine Abstract: 12.1 Introduction 12.2 Microfluidics 12.3 Testing of nanomedicine with microfluidic instruments 12.4 Delivery of nanomedicine using microfluidic technology 12.5 Nanoparticles 12.6 Conclusions and future trends Chapter 13: Zinc oxide nanowires for biomedical sensing and analysis Abstract: 13.1 Introduction 13.2 Electrode growth and preparation 13.3 Sensors and functionalization 13.4 Measurement and results 13.5 Conclusions Part III: Nanomedicine for soft tissue engineering Chapter 14: Nanotechnology and tissue-engineered organ regeneration Abstract: 14.1 Introduction 14.2 Nanotechnology and tissue engineering 14.3 Nanotechnology and organ regeneration 14.4 Future trends and challenges Chapter 15: Rapid fabrication of biomimetic nanofiber-enabled skin grafts Abstract: 15.1 Introduction 15.2 Autologous skin tissue engineering for wound healing 15.3 The effects of microenvironment on the formation of skin substitute 15.4 Production of biomimetic nanofibers using electrostatic spinning 15.5 Layer-by-layer assembly of cells into 3-D constructs using electrospun nanofibers 15.6 Rapid formation of skin grafts using the nanofiber-enabled cell-layering approach 15.7 Future trends and challenges 15.8 Conclusion 15.9 Acknowledgment Chapter 16: Nanotubes for tissue engineering Abstract: 16.1 Introduction 16.2 Nanotubes for tissue engineering 16.3 Nanotube applications in tissue engineering 16.4 Nanotubes and their effects 16.5 Conclusions Chapter 17: Self-assembled nanomaterials for tissue-engineering applications Abstract: 17.1 Introduction 17.2 Peptide-based self-assembled nanomaterials 17.3 Applications of peptide-based materials in tissue engineering 17.4 Nucleic acid-based nanomaterials 17.5 Applications of rosette nanotubes (RNTs) in bone and cartilage tissue engineering Part IV: Nanomedicine for bone and cartilage tissue engineering Chapter 18: Electrically active biocomposites as smart scaffolds for bone tissue engineering Abstract: 18.1 Introduction 18.2 Composition and electrical properties of natural bone 18.3 Effect of an external E-field on cells 18.4 Development of hydroxyapatite (HA)-based bone replacement materials 18.5 Conclusions 18.6 Acknowledgement Chapter 19: Nanotechnology for cartilage and bone regeneration Abstract: 19.1 Introduction 19.2 Cartilage repair and regeneration 19.3 Bone repair and regeneration 19.4 Future trends and conclusions Chapter 20: Nanostructured materials for bone tissue replacement Abstract: 20.1 Introduction 20.2 The need for nano-engineered bone 20.3 Surface properties of orthopedic materials 20.4 Nano coating on conventional surfaces 20.5 Nanomaterials for orthopedic tissue engineering 20.6 Future trends and ethical concerns 20.7 Conclusions Chapter 21: Nanocomposites for cartilage regeneration Abstract: 21.1 Introduction 21.2 Design criteria and considerations for cartilage biomaterials 21.3 Biomaterials for cartilage regeneration 21.4 Scaffold fabrication 21.5 Conclusions and future trends Index

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Author Information

Dr Thomas J. Webster is an associate professor for the Division of Engineering and Department of Orthopaedics at Brown University, USA. He directs the Nanomedicine laboratory which designs, synthesizes, and evaluates nanomaterials for various implant applications and is noted for his work in this area.

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