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OverviewMyelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients. Full Product DetailsAuthor: Ian D. Duncan , Robin J M FranklinPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2012 Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 23.50cm Weight: 0.623kg ISBN: 9781461422174ISBN 10: 1461422175 Pages: 290 Publication Date: 31 August 2012 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Not yet available  This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release. Table of ContentsReviewsFrom the book reviews: The textbook discusses the cellular and molecular mediators of demyelination and regeneration of myelin support. It does a credible and well evidenced job at these two goals. National and international experts contribute to the dialogue. I recommend this book to neurologists, neuroscientists, neurosurgeons . (Joseph J. Grenier, Amazon.com, August, 2014) From the book reviews: The textbook discusses the cellular and molecular mediators of demyelination and regeneration of myelin support. It does a credible and well evidenced job at these two goals. National and international experts contribute to the dialogue. ... I recommend this book to neurologists, neuroscientists, neurosurgeons ... . (Joseph J. Grenier, Amazon.com, August, 2014) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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