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OverviewSeveral breast cancer susceptibility genes had been identified; among those are BRCA1 and BRCA2. Breast cancer is the predominant phenotype associated with mutations in BRCA1 and BRCA2 genes. However, the rate of mutations within the coding regions of the breast cancer susceptibility gene BRCA2 does not fairly explain the pathogenecity of the disease, nor accounting for all disease causing mutations. The aim of this study was to detect mutations that might affect the splicing of exon12 of the BRCA2 gene and thus modulating the functions of BRCA2∆12 variant in particular and its contribution to the overall biological functions of BRCA2 in DNA repair and tumor suppression. The structural and functional consequences for the corresponding protein will help to understand the role played by different BRCA2 variants in breast cancer. Full Product DetailsAuthor: Mohamed Hala TahaPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.90cm , Length: 22.90cm Weight: 0.231kg ISBN: 9783659437229ISBN 10: 3659437220 Pages: 152 Publication Date: 24 March 2015 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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