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OverviewThis book is composed of a set of chapters contributed by past and present collaborators of the Nobel laureate Sir Andrew Huxley, covering the areas of muscle research to which he has made major contributions. The purpose of the book is to discuss the way that muscle works, asking questions at a fundamental level about the molecular basis of muscle tone production and muscle contraction. The majority of the chapters are concerned with muscle physiology and the relation between structure and function. The process of activation of muscle is dealt with, together with the mechanism of contraction itself. Although most of the book concerns itself with vertebrate skeletal muscle, several of the chapters deal with cardiac muscle. The book also features two introductory chapters discussing Sir Andrew's achievements in both nerve and muscle physiology. All those interested in the structure and function of muscle, or cell motility in general, will wish to read this book. Full Product DetailsAuthor: Robert M. Simmons (King's College London)Publisher: Cambridge University Press Imprint: Cambridge University Press (Virtual Publishing) ISBN: 9780511574672ISBN 10: 0511574673 Publication Date: 07 September 2010 Audience: Professional and scholarly , Professional & Vocational Format: Undefined Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsContributors; Preface; 1. A. F. Huxley: an essay on his personality and his work on nerve physiology Robert Stampfli; 2. A. F. Huxley's research on muscle Robert M. Simmons; 3. Ultra-slow, slow, intermediate and fast inactivation of human sodium channels Reinhardt Rüdel and Bernd Fakler; 4. The structure of the triad: local stimulation experiments then and now Clara Lara Rranzini-Armstrong; 5. The calcium-induced calcium release mechanism in skeletal muscle and its modification by drugs Makoto Endo; 6. Hypodynamic tension changes in the frog heart Rolf Niedergerke and Sally Page; 7. Regulation of contractile proteins in heart muscle Saul Winegrad; 8. Differential activation of myofibrils during fatigue in twitch skeletal muscle fibres of the frog Hugo Gonzalez-Serratos and Maria del Carmen Garcia; 9. High-speed digital imaging microscopy of isolated muscle cells Stuart R. Taylor and Kenneth P. Ross; 10. Inotropic mechanism of myocardium Lincoln E. Ford; 11. Regulation of muscle contraction: dual role of calcium and cross-bridges Albert M. Gordon; 12. Fibre types in Xenopus muscle and their functional properties Jan Lännergren; 13. An electron microscopists's role in experiments on isolated muscle fibres Lucy M. Brown; 14. Structural changes accompanying mechanical events in muscle contraction Robert M. Simmons; 15. Mechano-chemistry of negatively strained cross-bridges in skeletal muscle Yale E. Goldman; 16. The force response during steady lengthening of active single muscle fibres of the frog Vincenzo Lombardi.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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