Overview

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.

Full Product Details

Author:   Rassier Dilson J.E
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2010 ed.
Volume:   682
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.563kg
ISBN:  

9781461426639

ISBN 10:   1461426634
Pages:   354
Publication Date:   06 November 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1, Striated Muscles: From Molecules To Cells D. E. Rassier Chapter 2, Contractile Performance Of Striated Muscle K. A. P. Edman Chapter 3, Energy Economy In The Actomyosin Interaction: Lessons From Simple Models S. L. Lehman Chapter 4, A Strain-Dependency Of Myosin Off-Rate Must Be Sensitive To Frequency To Predict The B-Process Of Sinusoidal Analysis B. M. Palmer Chapter 5, Electron Microscopic Visualization Of The Cross-Bridge Movement Coupled With Atp Hydrolysis In Muscle Thick Filaments In Aqueous Solution, Reminiscences And Future Prospects H. Sugi Chapter 6, Role Of Titin In Skeletal Muscle Function And Disease C. A. C. Ottenheijm, H. Granzier Chapter 7, Contractile Characteristics Of Sarcomeres Arranged In Series Or Mechanically Isolated From Myofibrils D. E. Rassier, I. Pavlov Chapter 8, The Force-Length Relationship Of Mechanically Isolated Sarcomeres W. Herzog, V. Joumaa, T. R. Leonard Chapter 9, Extraction And Replacement Of The Tropomyosin-Troponin Complex In Isolated Myofibrils B. Scellini, N. Piroddi , C. Poggesi, C. Tesi Chapter 10, Stretch And Shortening Of Skeletal Muscles Activated Along The Ascending Limb Of The Force-Length Relation D. E. Rassier, C. Pun Chapter 11, Cross-Bridge Properties In Single Intact Frog Fibers Studied By Fast Stretches B. Colombini, M. Nocella, G. Benelli, G. Cecchi, M. A. Bagni Chapter 12, Crossbridge And Non-Crossbridge Contributions To Force In Shortening And Lengthening Muscle K. W. Ranatunga, H. Roots, G. J. Pinniger, G. W. Offer Chapter 13, Short-Range Mechanical Properties Of Skeletal And Cardiac Muscles K. S. Campbell Chapter 14, Crossbridge Mechanism(S) Examined By Temperature Perturbation Studies On Muscle K. W. Ranatunga, M. E. Coupland Chapter 15, Efficiency Of Cross-Bridges And Mitochondria In Mouse Cardiac Muscle C. J. Barclay, C. Widén Chapter 16, Mechanisms Of Skeletal Muscle Weakness H. Westerblad, N. Place, T. Yamada Chapter 17, Stretch-Induced Membrane Damage In Muscle:Comparison Of Wild-Type And Mdx Mice D. G. Allen, B. Zhang, N. P. Whitehead Chapter 18, Cellular And Whole Muscle Studies Of Activity Dependent Potentiation B. R. Macintosh

Reviews

From the reviews: This text is ideally suited for muscle neurophysiologists interested in doing lab research aimed to study the strength of contraction of the actinmyosin units of skeletal and cardiac myofilaments. ... This text is ideal for neurophysiologists and mycologists who have any interest in recordings. I also recommend it for those who work with muscle spindles ... . (Joseph J. Grenier, Amazon.com, December, 2013)

From the reviews: “This text is ideally suited for muscle neurophysiologists interested in doing lab research aimed to study the strength of contraction of the actinmyosin units of skeletal and cardiac myofilaments. … This text is ideal for neurophysiologists and mycologists who have any interest in recordings. I also recommend it for those who work with muscle spindles … .” (Joseph J. Grenier, Amazon.com, December, 2013)

From the reviews: This text is ideally suited for muscle neurophysiologists interested in doing lab research aimed to study the strength of contraction of the actinmyosin units of skeletal and cardiac myofilaments. ... This text is ideal for neurophysiologists and mycologists who have any interest in recordings. I also recommend it for those who work with muscle spindles ... . (Joseph J. Grenier, Amazon.com, December, 2013)

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