Overview

The gastrointestinal mucosal defense system serves to minimize mucosal injury by either ingested or endogenously produced noxious substances. The mucosal defense system is stratified into pre-epithelial (alkaline mucus), epithelial (dynamic epithelial lining), and post-epithelial (microcirculation) components. The mucus lining the epithelial surface presents a diffusional barrier to ingested material (e.g., lipids) and also serves as an unstirred layer in which a pH gradient can be established to prevent acid-induced injury. The epithelial lining prevents entrance of any toxic material to the interstitium and, should it be damaged, it is rapidly resealed by migration of adjacent viable epithelial cells to cover the defect. Any acid or other material that has entered the interstitium is washed out by an intense neurogenic hyperemia. In general, the mucosal defense system is quite effective and any adverse gastrointestinal effects associated with the normal course of nutrient assimilation are minimal. However, there are two situations in which the mucosal defense system is known to be ineffective and result in gastric mucosal injury: inadvertent ingestion of H. pylori. or intentional ingestion of NSAIDs. H. pylori can penetrate the mucus layers and cause epithelial injury and inflammation, while at the same time preventing its clearance by the host immune system. NSAIDs weaken the mucus layer and cause epithelial cell injury.

Full Product Details

Author:   Peter R. Kvietys ,  Ahmed Yaqinuddin ,  Wael Al Kattan ,  D. Neil Granger
Publisher:   Morgan & Claypool Publishers
Imprint:   Morgan & Claypool Publishers
Dimensions:   Width: 19.10cm , Height: 0.90cm , Length: 23.50cm
Weight:   0.332kg
ISBN:  

9781615041473

ISBN 10:   1615041478
Pages:   172
Publication Date:   01 November 2014
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Acknowledgments Introduction The Mucus Layer Epithelial Lining Gastrointestinal Circulation Integration of Mucosal Defense Mucosal Defense System: Physiologic Mucosal Defense System: H. pylori Mucosal Defense System: Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) Overall Summary and Conclusions References Author Biographies

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Author Information

College of Medicine, Alfaisal University, Riyadh, KSA

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