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OverviewInfectious fungal diseases continue to take their toll in terms of human suffering and enormous economic losses. Invasive infections by opportunistic fungal pathogens are a major cause of morbidity and mortality in immuno-compromised individuals. At the same time, plant pathogenic fungi have devastating effects on crop production and human health. New strategies for antifungal control are required to meet the challenges posed by these agents, and such approaches can only be developed through the identification of novel biochemical and molecular targets. However, in contrast to bacterial pathogens, fungi display a wealth of “lifestyles” and modes of infection. This diversity makes it extremely difficult to identify individual, evolutionarily conserved virulence determinants and represents a major stumbling block in the search for common antifungal targets. In order to activate the infection programme, all fungal pathogens must undergo appropriate developmental transitions that involve cellular differentiation and the introduction of a new morphogenetic programme. How growth, cell cycle progression and morphogenesis are co-ordinately regulated during development has been an active area of research in fungal model systems such as budding and fission yeast. By contrast, we have only limited knowledge of how these developmental processes shape fungal pathogenicity, or of the role of the cell cycle and morphogenesis regulators as true virulence factors. This book combines state-of-the-art expertise from diverse pathogen model systems to update our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi. Full Product DetailsAuthor: José Pérez Martín , Antonio Di PietroPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Volume: 22 Dimensions: Width: 15.50cm , Height: 1.80cm , Length: 23.50cm Weight: 0.462kg ISBN: 9783642428340ISBN 10: 3642428347 Pages: 286 Publication Date: 22 February 2014 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsMolecular basis of morphogenesis in fungi.- Tropic orientation responses of pathogenic fungi.- Hyphal fusion.- Signalling of infectious growth in Fusarium oxysporum.- Integrating Cdk signaling in Candida albicans environmental sensing networks.- Cell cycle and morphogenesis connections during the formation of the infective filament in Ustilago maydis.- Appressorium Function in Colletotrichum orbiculare and Prospect for Genome Based Analysis.- Morphogenesis in Candida albicans: How to stay focused.- Morphogenesis in Paracoccidioides brasiliensi.- Morphogenesis of Cryptococcus neoformans.- Morphogenesis and infection in Botrytis cinere.- Morphogenesis, growth and development of the grass symbiont Epichlöe festucae.- Cryptococcus-neutrophil interaction.-ReviewsFrom the reviews: This book describes the molecular basis of morphogenesis and pathogenicity in the fungi and highlights new approaches. ... All the chapters are well organized and each chapter contains an introduction at the beginning and a conclusion at the last that can be very useful for the reader. ... This book is very important to scientists, researchers and teachers as well as students who are interested in fungal morphogenesis and pathogenicity. Therefore this book should be available in all schools, research laboratories, community and university libraries. (Kasun M. Thambugala, Fungal Diversity, Vol. 57 (1), November, 2012) From the reviews: This book describes the molecular basis of morphogenesis and pathogenicity in the fungi and highlights new approaches. ... All the chapters are well organized and each chapter contains an introduction at the beginning and a conclusion at the last that can be very useful for the reader. ... This book is very important to scientists, researchers and teachers as well as students who are interested in fungal morphogenesis and pathogenicity. Therefore this book should be available in all schools, research laboratories, community and university libraries. (Kasun M. Thambugala, Fungal Diversity, Vol. 57 (1), November, 2012) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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