Overview

A compendium of research in the field of medical mycology. • Measures the impact of genome projects, genetics, and molecular biology on the understanding of a diverse group of pathogenic fungi and explores the potential impact of vaccines and new therapeutic approaches to treatment. • Provides a broad overview of pathogenic fungi, including ascomycetes, basidiomycetes, zygomycetes, and both rare and common infections. • Focuses on immunological aspects of infection involving innate, humoral, and cell-mediated immunity. • Features comprehensive coverage of everything from general principles to specific pathogens and vaccine development. • Offers an in-depth analysis of the host-pathogen relationship, and comtemplates future directions. • Serves as a valuable resource for students, fellows, instructors, researchers, specialists, clinicians, and anyone interested in the general field of microbial pathogenesis. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Full Product Details

Author:   Joseph Heitman ,  Scott G Filler ,  John E Edwards Jr. ,  Aaron P Mitchell
Publisher:   American Society for Microbiology
Imprint:   American Society for Microbiology
Dimensions:   Width: 22.40cm , Height: 3.70cm , Length: 28.80cm
Weight:   1.556kg
ISBN:  

9781555813680

ISBN 10:   1555813682
Pages:   700
Publication Date:   01 April 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Table of Contents I. General Principles 1. Fungal Molecular Pathogenesis: What Can It Do and Why Do We Need It? John R. Perfect and Arturo Casadevall 2. Sex, MAT, and the Evolution of Fungal Virulence, James A. Fraser and Joseph Heitman 3. Post-Genomic Strategies for Genetic Analysis: Insight from Saccharomyces cerevisiae and Candida albicans, Clarissa J. Nobile and Aaron P. Mitchell 4. Candida albicans Hypha Formation and Virulence, Paula Sundstrom 5. The Conversion from Classical Studies in Fungal Pathogenesis to the Molecular Era, Kyung J. Kwon-Chung and Brian L. Wickes 6. Mating and Parasexual Genetics in Candida albicans, Matthew Miller and Alexander Johnson 7. The Mating-Type Locus and Mating of Candida albicans and Candida glabrata, David R. Soll 8. Evolution of Human Pathogenic Fungi: Phylogenies and Species, John W. Taylor 9. Establishment of Cell Identity in Pathogenic Fungi, Christina M. Hull 10. Signal Transduction in the Interactions of Fungal Pathogens and Mammalian Hosts, Malcolm Whiteway and Catherine Bachewich 11. Function and Regulation of Adhesin Gene Families in Saccharomyces cerevisiae, Candida albicans, and Candida glabrata, Irene Castano, Alejandro De Las Penas, and Brendan P. Cormack 12. Fungal Biofilms: Agents of Disease and Drug Resistance, Gordon Ramage, Mahmoud A. Ghannoum, and Jose L. Lopez-Ribot 13. Molecular Basis of Fungal Adherence to Endothelial and Epithelial Cells, Scott G. Filler, Donald C. Sheppard, and John E. Edwards, Jr. 14. Molecular Principles of Antifungal Drug Resistance, Dominique Sanglard and Theodore C. White II. Model Systems: Heterologous Hosts, Model Pathogens, and Fungal-Bacterial Interactions 15. Heterologous Hosts and the Evolution and Study of Fungal Pathogenesis, Eleftherios Mylonakis, Stephen B. Calderwood, and Frederick M. Ausubel 16. Amoeba and Slime Mold: Hosts of Virulence Evolution, Arturo Casadevall 17. Aspergillus nidulans: a Model for Elucidation of Aspergillus fumigatus Secondary Metabolism, Nancy Keller 18. Saccharomyces cerevisiae: an Emerging and Model Pathogenic Fungus, John H. McCusker 19. Fungal-Bacterial Interactions, Deborah A. Hogan and Roberto Kolter 20. Amphibian Chytridiomycosis as an Emerging Infectious Disease of Wildlife: What Can We Learn from the Earliest Diverging Fungi? Timothy Y. James and Rytas Vilgalys III. Specific Pathogens 21. Cryptococcus neoformans: a Sugar-Coated Killer, John R. Perfect 22. Towards a Molecular Understanding of Candida albicans Virulence, Frank C. Odds, Neil A. R. Gow, and Alistair J. P. Brown 23. Molecular Determinants of Histoplasma capsulatum Pathogenesis, Jon P. Woods 24. Molecular Determinants of Virulence in Aspergillus fumigatus, Judith C. Rhodes and Axel A. Brakhage 25. Pathogenesis of Pneumocystis, A. George Smulian and Melanie T. Cushion 26. Virulence Mechanisms of Coccidioides, Garry T. Cole, Jianmin Xue, Kalpathi Seshan, Priscila Borra, Ricardo Borra, Eric Tarcha, Ruth Schaller, Jie-Juen Yu, and Chiung-Yu Hung 27. Blastomyces dermatitidis Cell Surface Determinants and Their Application in Vaccine Development, Bruce Klein 28. Virulence Factors in Black Molds with Emphasis on Melanin, Chitin, and Wangiella as a Molecularly Tractable Model, Paul J. Szaniszlo 29. Zygomycetes as Agents of Infectious Disease in Humans, Ashraf S. Ibrahim and Brad Spellberg 30. Signaling Pathways in the Dimorphic Human Fungal Pathogen Penicillium marneffei, Alex Andrianopoulos and Sophie Zuber IV. The Host 31. Innate Humoral Immunity to Fungi, Thomas R. Kozel 32. Innate and Acquired Cellular Immunity to Fungi, Luigina Romani 33. Acquired Antibody-Mediated Immunity to Fungi, Liise-Anne Pirofski and Arturo Casadevall 34. Site-Specific Mucosal Immunity to Fungi: Lessons Learned from Candida albicans Applied to Other Fungi, Paul L. Fidel, Jr., and Beatriz Finkel-Jimenez 35. Intracellular Pathogenesis of Histoplasma capsulatum, Simon L. Newman 36. Interactions of Immune Cells with the Facultative Intracellular Pathogen Cryptococcus neoformans, Lauren E. Yauch and Stuart M. Levitz 37. Fungal Interactions with Leukocytes, Mairi C. Noverr, Dennis M. Lindell, Galen B. Toews, and Gary B. Huffnagle 38. Fungal Vaccine Development, Joshua D. Nosanchuk and George S. Deepe, Jr. 39. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, Thomas J. Walsh, Emmanuel Roilides, Karoll Cortez, and Caron Lyman V. Future Directions 40. Studying Fungal Virulence Using Genomics, Michael C. Lorenz 41. Future of Functional Genomics of Histoplasma capsulatum, Anita Sil and Lena Hwang 42. Functional Genomic Approaches to Fungal Pathogenesis, Drug Target Validation, and Antifungal Drug Discovery, Ainslie B. Parsons, Howard Bussey, and Charles Boone 43. Genetic and Proteomic Analysis of Fungal Virulence, Jennifer K. Lodge and Michael C. Lorenz 44. Genomic Perspectives on the Fungal Kingdom, Jason E. Stajich and Fred S. Dietrich

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