Overview

Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.

Full Product Details

Author:   Zhao-Wen Wang
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Second Edition 2023
Volume:   33
ISBN:  

9783031342318

ISBN 10:   3031342313
Pages:   401
Publication Date:   25 August 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The Architecture of the Presynaptic Release Site.-Cytomatrix Proteins in Presynaptic Terminal. -  Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse.-  Roles of SNARE Proteins in Synaptic Vesicle Fusion.- Calcium Sensors of Neurotransmitter Release. - Roles and Sources of Calcium in Synaptic Exocytosis.- Regulation of Presynaptic Calcium Channels.-  Roles of mUnc13/UNC-13 and mUnc18/UNC-18 in Neurotransmitter Release. - The role of tomosyn in the regulation of neurotransmitter exocytosis. -Roles of complexins in Neurotransmitter Release. -Regulation of Neurotransmitter Release by AIPR-1/AIP and calstabins. - The Role of Potassium Channels in the Regulation of Neurotransmitter Release.- Roles of Neuropeptides in Synaptic Function. - Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules. - Lipids and Secretory Vesicle Exocytosis.- Synaptic Vesicle Endocytosis.

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Author Information

​Zhao-Wen Wang, PhD, is Professor of Neuroscience in the Faculty of Neuroscience, Cell Biology, and Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut.  His major research interests are on the functions and regulation of the BK channel and gap junctions, and molecular mechanisms of neurotransmitter release. 

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