Overview

This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.   

Full Product Details

Author:   Rafal P. Piprek
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   58
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.682kg
ISBN:  

9783319811673

ISBN 10:   3319811673
Pages:   434
Publication Date:   31 May 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Early Development of the Gonads – Origin and Differentiation of the Somatic Cells of the Genital Ridges.- The formation and migration of primordial germ cells in mouse and man.- The Gonadal Supporting Cell Lineage and Mammalian Sex Determination: the Differentiation of Sertoli and Granulosa Cells.- Mesonephric cell migration into the gonads and vascularization are processes crucial for testis development.- Origin and Differentiation of Androgen-producing Cells in the Gonads.- Germ cell commitment to oogenic versus spermatogenic pathway - the role of retinoic acid.- Ovarian Folliculogenesis.- Control of oocyte growth and development by intercellular communication within the follicular niche.- Biology of the Sertoli cell in the Fetal, Pubertal and Adult Mammalian Testis.- Mechanisms Regulating Spermatogonial Differentiation.- Stem cells in mammalian gonads.- A Role of microRNAs in Cell Differentiation during Gonad Development.- The Battle of the Sexes: Human Sex Development and its Disorders.- Methods for the study of gonadal development.

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