Overview

Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.

Full Product Details

Author:   Hubert Hilbi
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2014 ed.
Volume:   376
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   5.856kg
ISBN:  

9783642405907

ISBN 10:   3642405908
Pages:   295
Publication Date:   31 October 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts.- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors.- Facets of small RNA-mediated regulation in Legionella pneumophila.- Type II secretion and Legionella virulence.- Effector translocation by the Legionella Icm/Dot type IV secretion system.- Modulation of small GTPases by Legionella.- Host lipidation: A mechanism for spatial regulation of Legionella effectors.- Phosphoinositides and the Legionella pathogen vacuole.- Legionella phospholipases implicated in virulence.- Cytotoxic glucosyltransferases of Legionella pneumophila.- Modulation of the ubiquitination machinery by Legionella.- Host signal transduction and protein kinases implicated in Legionella infection.- Mouse models of Legionnaires´ disease.

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