Overview

Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.

Full Product Details

Author:   Amit Singh ,  Madhuri Kango-Singh
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2013
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   5.796kg
ISBN:  

9781493953035

ISBN 10:   1493953036
Pages:   368
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Early eye development: Specification and Determination.- Molecular genetic mechanisms of axial patterning: Mechanistic insights into generation of axes in the developing eye.- Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow.- Cell Morphogenesis.- Cell Polarity in Drosophila Retina.- Negative regulation for neural patterning in the Drosophila eye.- Cell Adhesion during Drosophila eye development.- Modulation of Developmental Signaling by the Proteostasis Network.- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways.- Contribution of the Drosophila eye to unraveling the basis of neurodegeneration.- Genetic regulation of early eye development in non-dipteran insects.- Development and evolution of the Drosophila Bolwig's organ: a compound eye relict.- Index.

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