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Author:   Akio Kanai ,  Allen W. Nicholson
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
ISBN:  

9783032032997

ISBN 10:   3032032997
Pages:   296
Publication Date:   29 September 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Part I. Evolution of Transcription and Translation Systems.- Chapter 1. From Simplicity to Complexity: The Evolution of RNA Polymerase II from Its Archaeal Ancestor.- Chapter 2. Ancient Protein Folds in RNA Polymerase and Ribosomes.- Part II. Evolution of RNA Processing, Modification, and Decay Mechanisms.- Chapter 3. Regulation of Exon Recognition by Serine-Arginine Rich Splicing Factors and Heterogeneous Ribonucleoproteins in Higher Eukaryotes.- Chapter 4. Evolution of Bacterial tRNA Nucleotidyltransferase.- Chapter 5. Polyribonucleotide Phosphorylase: An Ancient Enzyme Conserved in Bacteria and Eukarya.- Chapter 6. RNA processing and Decay Pathways in Archaea: Emerging Insights of the Function of the Archaeal Specific Ski2-like RNA Helicase.- Part III. Evolution of Small RNA-Mediated Regulations.- Chapter 7. RNase III Enzymes and Their Accessory Domains.- Chapter 8. Conserved and Diverse Functions of Bacterial Small RNAs.- Chapter 9. Molecular Evolution of Bacterial RNase E and Its Systems.- Chapter 10. CRISPR – Cas Systems ~ Diversity and Evolution.- Chapter 11. Small Self-Cleaving Ribozymes in Eukaryotes.

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Author Information

Akio Kanai was born in Tokyo, Japan. He graduated from Waseda University in 1985 and obtained his PhD in molecular biology at the University of Tokyo in 1990. He finished postdoctoral training at the National Institutes of Health, USA (1990-1992), and he was appointed a researcher in the Tokyo Metropolitan Institute of Medical Science (1992-1996). He was a group leader for the Japan Science and Technology Corporation (JST), ERATO Project Group (1996-2001). He was an Associate Professor at the Institute for Advanced Biosciences, Keio University (2001-2006) and accepted a full professorship in April 2006 (concurrently serves as a professor at the Faculty of Environment and Information Studies, Keio University). Since 2022, he is also a professor of Systems Biology Program, Graduate School of Media and Governance, Keio University. His major research fields include molecular cellular biology and gene regulation in a variety of organisms. His work in life sciences has led him to his present research into RNA-binding proteins and non-coding RNAs. Allen Nicholson is a Professor of Biology in the College of Science and Technology at Temple University.  Prior to this appointment Dr. Nicholson was on the Biology faculty at Wayne State University, from 1985-2002. Dr. Nicholson received his bachelor’s degree in Chemistry from Cornell University in 1975 and his doctoral degree in Chemistry from the University of Pennsylvania in 1981. He was an NIH postdoctoral fellow at the Rockefeller University (1981-1985) where he developed his interests in RNA function in gene regulation. Although trained as a chemist, Dr. Nicholson established a distinguished career in molecular biology, and his research, which has been funded by the National Institutes of Health, has focused on understanding how genes are expressed and regulated at the post-transcriptional level. Specifically, Dr. Nicholson and his group are studying ribonucleases -- proteins whose role is to recognize and cut RNA molecules, and which exert profound effects on gene expression that controls cell growth and development. A specific ribonuclease under study, ribonuclease III, is a central participant in post-transcriptional gene expression and regulation in bacteria and has family members in eukaryotic systems with essential functions in gene expression and regulation. 

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