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OverviewFor many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA in the evolution of life itself. Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles as catalysts and regulatory molecules. Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment. Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever. Online Resource Centre The Online Resource Centre to accompany Molecular Biology of RNA features: For registered adopters: Figures from the book in electronic format Full Product DetailsAuthor: David Elliott , Michael LadomeryPublisher: Oxford University Press Imprint: Oxford University Press Dimensions: Width: 19.60cm , Height: 2.20cm , Length: 26.50cm Weight: 0.973kg ISBN: 9780199288373ISBN 10: 0199288372 Pages: 460 Publication Date: 02 December 2010 Audience: College/higher education , Tertiary & Higher Education Format: Paperback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of Contents1. Introduction to Molecular Biology of RNA ; 2. RNA can form versatile structures ; 3. Catalytic RNAs ; 4. The RNA-binding proteins ; 5. Co-transcriptional pre-mRNA processing ; 6. Pre-mRNA splicing by the spliceosome ; 7. How pre-mRNAs are decoded by the splicing machinery ; 8. Regulated RNA processing - alternative splicing ; 9. Pre-mRNA splicing defects in development and disease ; 10. Nucleocytoplasmic traffic of messenger RNA ; 11. Nucleocytoplasmic traffic of non-coding RNA ; 12. Messenger RNA localization ; 13. Translation of messenger RNA ; 14. Stability and degradation of mRNA ; 15. RNA editing ; 16. The biogenesis of non-coding RNAs ; 17. The 'mega RNAs': long non-coding RNAs with important roles in epigenetic regulation of gene expression ; 18. The short non-coding RNAs and gene silencingReviews<br> All aspects of RNA biology are described clearly... One type of molecule, one book, up to date... A book on RNA like this is just in time. - Dr. J. Kooter, Vrije Universiteit Amsterdam<p><br> There are currently no suitable textbooks (on Molecular Biology of RNA) that I am aware of, and thus this book fills a very useful niche. - Dr. S. Valadkhan, Case Western Reserve University<p><br> Author InformationDavid Elliott is a Reader in Genetics at the Institute of Human Genetics, Newcastle University, UK Michael Ladomery is Principal Investigator in the RNA Biology group, School of Life Sciences, University of the West of England, UK. Tab Content 6Author Website:Countries AvailableAll regions |
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