Overview

Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. The book also deals with the influence of both essential and non-essential transition metals on gene expression and the ability of cells to respond to extracellular signals. It covers the latest information on specific metals and the biological molecules (such as glutathione, metallothioneins, specific transporters, signal transduction proteins, and transcription factors) with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. A volume focusing on this area of research is timely, and makes a fertile meeting ground for the disciplines of molecular genetics and metal toxicology. Zalups; Rudolfs K. Mercer Univ School of Medicine, Macon, Georgia, USA,Koropatnick; D. James London Regional Cancer Center, Ontario, Canada,

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